Evidence map›Paper›PMID 36765718›Full record

ArticleCancers2023

Plasma nanoDSF Denaturation Profile at Baseline Is Predictive of Glioblastoma EGFR Status.

Rémi Eyraud, Stéphane Ayache, Philipp O Tsvetkov, Shanmugha Sri Kalidindi, Viktoriia E Baksheeva, Sébastien Boissonneau, Carine Jiguet-Jiglaire, Romain Appay, Isabelle Nanni-Metellus, Olivier Chinot and 2 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Tear nanoDSF Denaturation Profile Is Predictive of Glaucoma.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rémi EyraudLaboratoire Hubert Curien UMR 5516, UJM-Saint-Etienne, University Lyon, CNRS, 42000 Saint Etienne, France.ORCID 0000-0002-5728-4759
Stéphane AyacheLIS, Aix Marseille Univ, CNRS, 13288 Marseille, France.
Philipp O TsvetkovInst Neurophysiopathol, INP, Faculté des Sciences Médicales et Paramédicales, Aix Marseille Univ, CNRS, 13005 Marseille, France.ORCID 0000-0002-8622-8836
Shanmugha Sri KalidindiLaboratoire Hubert Curien UMR 5516, UJM-Saint-Etienne, University Lyon, CNRS, 42000 Saint Etienne, France.
Viktoriia E BaksheevaInst Neurophysiopathol, INP, Faculté des Sciences Médicales et Paramédicales, Aix Marseille Univ, CNRS, 13005 Marseille, France.
Sébastien BoissonneauDepartment of Neuro-Surgery, Timone Hospital, APHM, 13005 Marseille, France.
Carine Jiguet-JiglaireInst Neurophysiopathol, INP, Faculté des Sciences Médicales et Paramédicales, Aix Marseille Univ, CNRS, 13005 Marseille, France.
Romain AppayInst Neurophysiopathol, INP, Faculté des Sciences Médicales et Paramédicales, Aix Marseille Univ, CNRS, 13005 Marseille, France.ORCID 0000-0003-4545-6063
Isabelle Nanni-MetellusDepartment of Molecular Oncology, APHM, 13016 Marseille, France.
Olivier ChinotInst Neurophysiopathol, INP, Faculté des Sciences Médicales et Paramédicales, Aix Marseille Univ, CNRS, 13005 Marseille, France.
François DevredInst Neurophysiopathol, INP, Faculté des Sciences Médicales et Paramédicales, Aix Marseille Univ, CNRS, 13005 Marseille, France.ORCID 0000-0001-5990-8898
Emeline TabouretInst Neurophysiopathol, INP, Faculté des Sciences Médicales et Paramédicales, Aix Marseille Univ, CNRS, 13005 Marseille, France.ORCID 0000-0002-4031-2178

Funding

Cancéropôle PACA Recherche Translationnelle - GPPFrench National Alliance for Life Sciences and Health ITMO Cancer MIC - AI4OPFrench National Cancer Institute INCa-DGOS-Inserm_12560
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in adults. Recently, we demonstrated that plasma denaturation profiles of glioblastoma patients obtained using Differential Scanning Fluorimetry can be automatically distinguished from healthy controls with the help of Artificial Intelligence (AI). Here, we used a set of machine-learning algorithms to automatically classify plasma denaturation profiles of glioblastoma patients according to their EGFR status. We found that Adaboost AI is able to discriminate

Indexed as

biomarkercancerdifferential scanning fluorimetryglioblastomamachine learningneuro-oncologyneurophysiopathologyplasma profiling

Identifiers

PMID36765718
PMCPMC9913157

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.