Evidence map›Paper›PMID 36765828›Full record

ArticleCancers2023

Profile of MicroRNAs Associated with Death Due to Disease Progression in Metastatic Papillary Thyroid Carcinoma Patients.

Ana Kober Leite, Kelly Cristina Saito, Thérèse Rachell Theodoro, Fátima Solange Pasini, Luana Perrone Camilo, Carlos Augusto Rossetti, Beatriz Godoi Cavalheiro, Venâncio Avancini Ferreira Alves, Luiz Paulo Kowalski, Maria Aparecida Silva Pinhal and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ana Kober LeiteHead and Neck Surgery Department, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-010, SP, Brazil.ORCID 0000-0001-7814-757X
Kelly Cristina SaitoDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil.ORCID 0000-0001-6397-6754
Thérèse Rachell TheodoroDiscipline of Biochemistry, Department of Morfology and Physiology, Faculdade de Medicina Do ABC, São Paulo 09060-870, SP, Brazil.
Fátima Solange PasiniCentro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo Paulo (ICESP), Hospital das Clínicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, Sao Paulo 01246-000, SP, Brazil.ORCID 0000-0002-0361-7781
Luana Perrone CamiloFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo 05653-120, SP, Brazil.
Carlos Augusto RossettiFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Albert Einstein, São Paulo 05653-120, SP, Brazil.
Beatriz Godoi CavalheiroHead and Neck Surgery Department, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-010, SP, Brazil.
Venâncio Avancini Ferreira AlvesPathology Department, Instituto do Câncer do Estado de São Paulo, Laboratório de Investigação Médica 14 (LIM14), Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-903, SP, Brazil.
Luiz Paulo KowalskiHead and Neck Surgery Department, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-010, SP, Brazil.
Maria Aparecida Silva PinhalDiscipline of Biochemistry, Department of Morfology and Physiology, Faculdade de Medicina Do ABC, São Paulo 09060-870, SP, Brazil.
Edna Teruko KimuraDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil.ORCID 0000-0001-8403-4459
Leandro Luongo MatosHead and Neck Surgery Department, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-010, SP, Brazil.

Funding

National Council for Scientific and Technological Development 407520/2018-0
6 · The paper itself

Abstract

Papillary thyroid carcinoma (PTC) is the most common neoplasm of the endocrine system and has an excellent long-term prognosis, with low rates of distant metastatic disease. Although infrequent, there are cases of deaths directly related to PTC, especially in patients with metastatic disease, and the factors that could be associated with this unfavorable outcome remain a major challenge in clinical practice. Recently, research into genetic factors associated with PTC has gained ground, especially mutations in the TERT promoter and BRAF gene. However, the role of microRNAs remains poorly studied, especially in those patients who have an unfavorable outcome at follow-up. This paper aims to evaluate molecular markers related to the different pathological processes of PTC, as well as the histological characteristics of the neoplasm, and to compare this profile with prognosis and death from the disease using an analysis of patients treated for metastatic disease in a single tertiary cancer center. Evaluation of microRNA expression in paraffin-embedded tumor specimens was carried out by quantitative PCR using the TaqMan

Indexed as

deathmicroRNAsmolecular biologypapillary thyroid carcinomaprognosis

Identifiers

PMID36765828
PMCPMC9913691

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.