Evidence map›Paper›PMID 36766633›Full record

ArticleDiagnostics (Basel, Switzerland)2023

High Plasma Levels of Neopterin Are Associated with Increased Mortality among Children with Severe Malaria in Benin.

Samuel Odarkwei Blankson, Lauriane Rietmeyer, Patrick Tettey, Liliane Dikroh, Bernard Tornyigah, Rafiou Adamou, Azizath Moussiliou, Caroline Padounou, Annick Amoussou, Benedicta Ayiedu Mensah and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Samuel Odarkwei BlanksonMERIT, IRD, Université de Paris Cité, 75006 Paris, France.ORCID 0000-0002-8963-6595
Lauriane RietmeyerMERIT, IRD, Université de Paris Cité, 75006 Paris, France.ORCID 0000-0002-8795-651X
Patrick TetteyDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra LG 54, Ghana.ORCID 0000-0002-6060-9497
Liliane DikrohDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra LG 54, Ghana.ORCID 0000-0003-4201-2133
Bernard TornyigahMERIT, IRD, Université de Paris Cité, 75006 Paris, France.
Rafiou AdamouInstitut de Recherche Clinique du Benin (IRCB), Calavi, Benin.ORCID 0000-0001-5506-1095
Azizath MoussiliouInstitut de Recherche Clinique du Benin (IRCB), Calavi, Benin.ORCID 0000-0001-6736-9476
Caroline PadounouCentre Hospitalier Universitaire de l'Oueme, Porto-Novo, Benin.
Annick AmoussouService de Pédiatrie, Centre Hospitalo-Universitaire, Suruléré (CHU-Suruléré), Cotonou, Benin.
Benedicta Ayiedu MensahDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra LG 54, Ghana.
Maroufou J AlaoDépartement de Pédiatrie, Hôpital Mère-Enfant la Lagune (CHUMEL), Cotonou, Benin.
Gordon AwandareWest African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra LG 54, Ghana.
Nicaise Tuikue NdamMERIT, IRD, Université de Paris Cité, 75006 Paris, France.
Christian RoussilhonInstitut Pasteur, 28 Rue du Docteur Roux, 75015 Paris, France.
Rachida TaharMERIT, IRD, Université de Paris Cité, 75006 Paris, France.

Funding

Institut Mérieux (France) G74882-2017 - Dr TAHAR
6 · The paper itself

Abstract

Among the barriers to accessing adequate treatment and high-level monitoring for malaria febrile patients is the lack of effective prognostic markers. Neopterin, which is a marker of monocyte/macrophage activation, was found have increased during severe malaria. In this study, we used quantitative ELISA in order to assess the levels of plasma soluble neopterin in 151 patients from a cohort of Beninese children with severe malaria. We evaluated the prognostic accuracy of this molecule in order to predict the outcome of the disease. Our results show that neopterin levels were not significantly different between patients with different forms of severe malaria, including severe non-cerebral malaria (SNCM) and cerebral malaria (CM). However, the levels of this molecule were found to be higher in patients with severe malarial anemia (SMA) among both CM and SNCM cases (

Indexed as

anemiaBenincerebral malarianeopterinPlasmodium falciparumsevere malaria

Identifiers

PMID36766633
PMCPMC9914932

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.