Trial reportInternational journal of environmental research and public health2023
Time of Day and Chronotype-Dependent Synchrony Effects Exercise-Induced Reduction in Migraine Load: A Pilot Cross-Over Randomized Trial.
Trial report in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04553445 (Temporal, Environmental, and Genetic Factors Regulating Exercise and Migraine), which is not on this map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Temporal, Environmental, and Genetic Factors Regulating Exercise and Migraine
Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Exercise in a natural environment increases program compliance in people with chronic migraine: A pilot cross-over randomized trial.Journal of bodywork and movement therapies · 2024Trial
- Epidemiology of primary headache and lifestyle factors among children and adolescents: a regional school-based study in China.The journal of headache and pain · 2026Article
- Evening Chronotype Associates With Worse Physical and Mental Health and Headache-Related Disability Among Migraine Patients.Journal of sleep research · 2025Article
- Exercise Patterns and Migraine Management: A Multifaceted Approach.American journal of lifestyle medicine · 2025Article
- Time-restricted eating, the clock ticking behind the scenes.Frontiers in pharmacology · 2024Review
- Sleep and chronotype influence aerobic performance in young soccer players.Frontiers in physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Migraines are the most common cause of chronic pain. Effective, non-pharmacological strategies to reduce migraine load, like exercise, are needed, but it is unclear how exercise timing and chronotype modulate the effects. We sought to determine the effects of time-of-day of exercise, and synchrony with one's chronotype, on migraine load. We performed a pilot cross-over randomized trial where participants with chronic migraine completed two one-month exercise interventions, consisting of either morning exercise (before 09:00 a.m.) or evening exercise (after 7:00 p.m.) in a randomized repeated measures cross-over design (Clinical Trial #NCT04553445). Synchrony was determined by exercise time and chronotype (i.e., a morning type participant exercising in the morning is 'in-sync,' while an evening type participant exercising in the morning is 'out-of-sync'). Migraine burden, and anthropometric assessment occurred before and after each month of exercise. Data was analyzed using repeated measures ANOVA with significance accepted at
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.