Evidence map›Paper›PMID 36767980›Full record

Observational studyInternational journal of environmental research and public health2023

SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes.

Rosa Sessa, Simone Filardo, Luisa Masciullo, Marisa Di Pietro, Antonio Angeloni, Gabriella Brandolino, Roberto Brunelli, Rossella D'Alisa, Maria Federica Viscardi, Emanuela Anastasi and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rosa SessaMicrobiology Section, Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.
Simone FilardoMicrobiology Section, Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-2730-8588
Luisa MasciulloDepartment of Maternal and Child Health and Urology, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0001-7344-4196
Marisa Di PietroMicrobiology Section, Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-0197-0485
Antonio AngeloniDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Gabriella BrandolinoDepartment of Maternal and Child Health and Urology, "Sapienza" University of Rome, 00161 Rome, Italy.
Roberto BrunelliDepartment of Maternal and Child Health and Urology, "Sapienza" University of Rome, 00161 Rome, Italy.
Rossella D'AlisaDepartment of Maternal and Child Health and Urology, "Sapienza" University of Rome, 00161 Rome, Italy.
Maria Federica ViscardiDepartment of Maternal and Child Health and Urology, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0003-0979-8832
Emanuela AnastasiDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0002-5124-3219
Maria Grazia PorporaDepartment of Maternal and Child Health and Urology, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0001-5556-3933

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the most threatening viral infections in the last decade. Amongst susceptible individuals, infected pregnant women might be predisposed to severe complications. Despite the extensive interest in SARS-CoV-2 research, the clinical course of maternal infection, the vertical transmission and the neonatal outcomes have not been completely understood yet. The aim of our study was to investigate the association between SARS-CoV-2 infection, obstetric outcomes and vertical transmission.

methodsA prospective observational study was performed, enrolling unvaccinated pregnant patients positive for SARS-CoV-2 (cases) and matched with uninfected pregnant women (controls). Maternal and neonatal nasopharyngeal swabs, maternal and cord blood, amniotic fluid and placenta tissue samples were collected; blood samples were tested for anti-S and anti-N antibodies, and histologic examination of placental tissues was performed.

resultsThe cases showed a significant association with the development of some obstetric complications, such as intrauterine growth restriction and pregnancy-associated hypothyroidism and diabetes, as compared to controls; their newborns were more likely to have a low birth weight and an arterial umbilical pH less than 7. The viral genome was detected in maternal and cord blood and placental samples in six cases.

conclusionsPregnant women positive for SARS-CoV-2 infection are more likely to develop severe obstetric outcomes; their newborns could have a low birth weight and arterial pH. Vertical transmission seems a rare event, and further investigation is strongly needed.

Indexed as

COVID-19Pregnancy Complications, InfectiousAntibodiesFemaleHumansInfant, Low Birth WeightInfant, NewbornInfectious Disease Transmission, VerticalPlacentaPregnancyPregnancy OutcomeSARS-CoV-2Antibodiesneonatal outcomespregnancy outcomesSARS-CoV-2vertical transmission

Identifiers

PMID36767980
PMCPMC9915124

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.