Evidence map›Paper›PMID 36768260›Full record

ArticleInternational journal of molecular sciences2023

Redox-Dependent Modulation of Human Liver Progenitor Cell Line Fate.

Francesco Bellanti, Domenica Mangieri, Giorgia di Bello, Aurelio Lo Buglio, Giuseppe Pannone, Maria Carmela Pedicillo, Alberto Fersini, Michał Dobrakowski, Aleksandra Kasperczyk, Sławomir Kasperczyk and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francesco BellantiDepartment of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0002-8196-7373
Domenica MangieriDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0001-7350-9383
Giorgia di BelloDepartment of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Aurelio Lo BuglioDepartment of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0003-1569-3658
Giuseppe PannoneDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0003-4198-407X
Maria Carmela PedicilloDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.
Alberto FersiniDepartment of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Michał DobrakowskiDepartment of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Katowice, Poland.
Aleksandra KasperczykDepartment of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Katowice, Poland.
Sławomir KasperczykDepartment of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Katowice, Poland.ORCID 0000-0001-8974-5786
Gianluigi VendemialeDepartment of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.

Funding

University of Foggia Progetti di Ricerca di Ateneo - Anno 2020
6 · The paper itself

Abstract

Redox homeostasis is determinant in the modulation of quiescence/self-renewal/differentiation of stem cell lines. The aim of this study consisted of defining the impact of redox modifications on cell fate in a human hepatic progenitor line. To achieve this, the HepaRG cell line, which shows oval ductular bipotent characteristics, was used. The impact of redox status on the balance between self-renewal and differentiation of HepaRG cells was investigated using different methodological approaches. A bioinformatic analysis initially proved that the trans-differentiation of HepaRG toward bipotent progenitors is associated with changes in redox metabolism. We then exposed confluent HepaRG (intermediate differentiation phase) to oxidized (H

Indexed as

Hydrogen PeroxideNF-E2-Related Factor 2Cell DifferentiationCell LineHepatocytesHumansLiverOxidation-ReductionStem CellsHydrogen PeroxideNF-E2-Related Factor 2HepaRGliver regenerationredox balance

Identifiers

PMID36768260
PMCPMC9916526

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.