Evidence map›Paper›PMID 36768394›Full record

ArticleInternational journal of molecular sciences2023

Trimethylamine N-Oxide Response to a Mixed Macronutrient Tolerance Test in a Cohort of Healthy United States Adults.

Kristen L James, Erik R Gertz, Catherine P Kirschke, Hooman Allayee, Liping Huang, Mary E Kable, John W Newman, Charles B Stephensen, Brian J Bennett

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02367287 (Assessing the Impact of Diet on Inflammation in Healthy and Obese Adults in a Cross-Sectional Phenotyping Study), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02367287 completednot on this map

Assessing the Impact of Diet on Inflammation in Healthy and Obese Adults in a Cross-Sectional Phenotyping Study

TypeobservationalSponsorUSDA, Western Human Nutrition Research CenterRan2015 to 2019Enrolled393ConditionsObesity, Inflammation
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kristen L JamesDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-3704-3560
Erik R GertzUSDA-ARS Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA.
Catherine P KirschkeUSDA-ARS Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA.
Hooman AllayeeDepartment of Population & Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Liping HuangDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Mary E KableDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-5485-6539
John W NewmanDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0001-9632-6571
Charles B StephensenDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Brian J BennettDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
West Health · USUniversity of California, Davis · USUniversity of Southern California · US

Funding

Biological Mechanisms through which TMAO Promotes AtherosclerosisR01HL148110 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN, SHIH, DIANA MOUHAN · 2020 to 2023
$2.5M
NHLBI NIH HHS R01 HL148110NIH HHS RO1HL148110
6 · The paper itself

Abstract

Plasma trimethylamine n-oxide (TMAO) concentration increases in responses to feeding TMAO, choline, phosphatidylcholine, L-carnitine, and betaine but it is unknown whether concentrations change following a mixed macronutrient tolerance test (MMTT) with limited amounts of TMAO precursors. In this proof-of-concept study, we provided healthy female and male adults (

Indexed as

BetaineCholineAdolescentAdultAgedFemaleHumansMaleMethylaminesMiddle AgedNutrientsRNA, Ribosomal, 16SYoung AdultBetaineCholineMethylaminesNutrientsRNA, Ribosomal, 16Strimethyloxaminebile acidscardiovascular diseasegut microbiotameal responsemetabolitesmetabolomicsmixed macronutrient tolerance testphosphatidylcholineprecision nutritiontrimethylamine-n oxide

Identifiers

PMID36768394
PMCPMC9917175
OpenAlexW4317538916

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.