Evidence map›Paper›PMID 36768458›Full record

ArticleInternational journal of molecular sciences2023

New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2.

Rebecca Ferrisi, Beatrice Polini, Caterina Ricardi, Francesca Gado, Kawthar A Mohamed, Giovanna Baron, Salvatore Faiella, Giulio Poli, Simona Rapposelli, Giuseppe Saccomanni and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Development and evaluation of deuterated [EJNMMI radiopharmacy and chemistry · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rebecca FerrisiDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-9709-766X
Beatrice PoliniDepartment of Pathology, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-2664-6091
Caterina RicardiDepartment of Pathology, University of Pisa, 56126 Pisa, Italy.
Francesca GadoDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milano, Italy.ORCID 0000-0003-2971-0834
Kawthar A MohamedCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Giovanna BaronDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milano, Italy.ORCID 0000-0002-9335-6318
Salvatore FaiellaDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Giulio PoliDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Simona RapposelliDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-0146-6358
Giuseppe SaccomanniDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Giancarlo AldiniDepartment of Pathology, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-2355-6744
Grazia ChielliniDepartment of Pathology, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-6703-5820
Robert B LaprairieCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.ORCID 0000-0002-9994-433X
Clementina ManeraDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Gabriella OrtoreDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.

Funding

Canadian Institutes of Health Research 2017014Italian Ministry of Health NET-2016-02363765University of Pisa . PRA_2020_58
6 · The paper itself

Abstract

Very recently, we have developed a new generation of ligands targeting the cannabinoid receptor type 2 (CB2R), namely

Indexed as

Allosteric SiteAllosteric RegulationHumansLigandsReceptors, CannabinoidLigandsReceptors, Cannabinoidallosteric modulatorsanti-inflammatory activitycannabinoid receptor type 2dockingdrug discoverydualsteric/bitopicendocannabinoid systemhuman microglial cells

Identifiers

PMID36768458
PMCPMC9917213

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.