Evidence mapPaperPMID 36768636Full record

ArticleInternational journal of molecular sciences2023

Dietary Walnuts Preserve Aspects of Health Span and Alter the Hippocampal Lipidome in Aged High-Fat Diet-Fed Mice.

Ardijana Novaj, Matthew G Engel, Ruixuan Wang, Kai Mao, Xiaonan Xue, Yam Amir, Gil Atzmon, Derek M Huffman

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ardijana NovajDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Matthew G EngelDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0003-3596-1584
Ruixuan WangDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kai MaoDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Xiaonan XueDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Yam AmirDepartment of Human Biology, University of Haifa, Haifa 3498838, Israel.ORCID 0000-0002-4900-6345
Gil AtzmonInstitute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0001-6895-3607
Derek M HuffmanDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Albert Einstein College of Medicine · USUniversity of Haifa · IL

Funding

WORD PROCESSORP30CA013330 · YESHIVA UNIVERSITY · 1985 to 2025
$27.5M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · YESHIVA UNIVERSITY · 1985 to 2005
$8.4M
California Walnut Commission no number assignedNCI NIH HHS P30 CA013330NIA NIH HHS P30 AG038072NIA NIH HHS R00 AG037574NIH HHS T32 GM007288
6 · The paper itself

Abstract

Evidence continues to accrue that aging and its diseases can be delayed by pharmacologic and dietary strategies that target the underlying hallmarks of the aging process. However, identifying simple, safe, and effective dietary strategies involving the incorporation of whole foods that may confer some protection against the aging process is also needed. Recent observational studies have suggested that nut consumption can reduce mortality risk in humans. Among these, walnuts are particularly intriguing, given their high content of n-3 fatty acids, fiber, and antioxidant and anti-inflammatory compounds. To this end, 12-month-old male CB6F1 mice were provided either a defined control low-fat diet (LFD), a control high-fat diet (HFD), or an isocaloric HFD containing 7.67% walnuts by weight (HFD + W), and measures of healthspan and related biochemical markers (

Indexed as

JuglansAgedAnimalsAntioxidantsDiet, High-FatHumansInfantLipidomicsMaleMiceMice, Inbred C57BLNutsWeight GainAntioxidantsagingdiethealthnuts

Identifiers

PMID36768636
PMCPMC9916809
OpenAlexW4317932815

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.