Evidence map›Paper›PMID 36768809›Full record

ArticleInternational journal of molecular sciences2023

The ANGPTL3-4-8 Axis in Normal Gestation and in Gestational Diabetes, and Its Potential Involvement in Fetal Growth.

Sergiy Klid, Elsa Maymó-Masip, Francisco Algaba-Chueca, Mónica Ballesteros, Montserrat Inglès-Puig, Albert Guarque, Ana Madeira, Carlos Jareño, Joan Vendrell, Sonia Fernández-Veledo and 1 more

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In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Effects ofEnvironmental science & technology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sergiy KlidDepartment of Medicine and Surgery, Rovira i Virgili University, 43005 Tarragona, Spain.ORCID 0000-0001-7006-9925
Elsa Maymó-MasipCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Carlos III Health Institute, 28029 Madrid, Spain.
Francisco Algaba-ChuecaCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Carlos III Health Institute, 28029 Madrid, Spain.ORCID 0000-0002-6537-1502
Mónica BallesterosDepartment of Medicine and Surgery, Rovira i Virgili University, 43005 Tarragona, Spain.ORCID 0000-0001-9997-2579
Montserrat Inglès-PuigDepartment of Medicine and Surgery, Rovira i Virgili University, 43005 Tarragona, Spain.
Albert GuarqueDepartment of Medicine and Surgery, Rovira i Virgili University, 43005 Tarragona, Spain.ORCID 0000-0003-2762-0704
Ana MadeiraCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Carlos III Health Institute, 28029 Madrid, Spain.
Carlos JareñoDepartament of Endocrinology and Nutrition, Research Unit, University Hospital of Tarragona Joan XXIII, Institut d'Investigació Sanitària Pere Virgili (IISPV), 43007 Tarragona, Spain.
Joan VendrellDepartment of Medicine and Surgery, Rovira i Virgili University, 43005 Tarragona, Spain.ORCID 0000-0002-6994-6115
Sonia Fernández-VeledoCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Carlos III Health Institute, 28029 Madrid, Spain.ORCID 0000-0003-2906-3788
Ana MegíaDepartment of Medicine and Surgery, Rovira i Virgili University, 43005 Tarragona, Spain.ORCID 0000-0002-5101-9452
Instituto de Salud Carlos III · ESInstitut de Recerca Biomèdica Catalunya Sud · ES

Funding

Agency for Administration of University and Research 2020FI_B 00980Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CB07708/0012Instituto de Salud Carlos III PI 15/01562Instituto de Salud Carlos III PI 18/00516Instituto de Salud Carlos III PI 20/00338Instituto de Salud Carlos III PI 21/01479Miguel Servet tenure-track program CP10/00438Miguel Servet tenure-track program CPII16/00008Spanish Ministry of Science and Innovation PID2021-122480OB-100Spanish Ministry of Science and Innovation RTI2018-093919-B-100
6 · The paper itself

Abstract

Dyslipidemia in gestational diabetes has been associated with worse perinatal outcomes. The ANGPTL3-4-8 axis regulates lipid metabolism, especially in the transition from fasting to feeding. In this study, we evaluated the response of ANGPTL3, 4, and 8 after the intake of a mixed meal in women with normal glucose tolerance and gestational diabetes, and we assessed their gene expressions in different placental locations. Regarding the circulating levels of ANGPTL3, 4, and 8, we observed an absence of ANGPTL4 response after the intake of the meal in the GDM group compared to its presence in the control group. At the placental level, we observed a glucose tolerance-dependent expression pattern of

Indexed as

Diabetes, GestationalAngiopoietin-Like Protein 3Angiopoietin-Like Protein 4Angiopoietin-Like Protein 8FemaleFetal DevelopmentGlucoseHumansParturitionPeptide HormonesPlacentaPregnancyAngiopoietin-Like Protein 3Angiopoietin-Like Protein 4Angiopoietin-Like Protein 8ANGPTL3 protein, humanANGPTL4 protein, humanANGPTL8 protein, humanGlucosePeptide HormonesANGPTLfetal growthgestational diabeteslipid metabolism

Identifiers

PMID36768809
PMCPMC9917010
OpenAlexW4318474771

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.