Evidence map›Paper›PMID 36768893›Full record

ReviewInternational journal of molecular sciences2023

Chrono-Nutrition: Circadian Rhythm and Personalized Nutrition.

Marica Franzago, Elisa Alessandrelli, Stefania Notarangelo, Liborio Stuppia, Ester Vitacolonna

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07123610 (The Relationship Between Mediterranean Diet Education Given to Shift-Working Nurses and Sleep Quality, Physical Activity Level, Blood Parameters, and Anthropometric Measurements), which is not on this map. Cited by 62 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07123610 nacompletednot on this mapstarted 2024, after this paper: background citation

The Relationship Between Mediterranean Diet Education Given to Shift-Working Nurses and Sleep Quality, Physical Activity Level, Blood Parameters, and Anthropometric Measurements

TypeinterventionalSponsorBahçeşehir UniversityRan2024 to 2024Enrolled130ConditionsCardiovascular Diseases, Obesity Prevention, Atheroscleroses, HypertensionArmsMediterranean Diet Education Program
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Food Intake According to Clock Gene Polymorphisms: A Systematic Review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marica FranzagoDepartment of Medicine and Aging, School of Medicine and Health Sciences, G. d'Annunzio University, 66100 Chieti, Italy.ORCID 0000-0002-4830-8034
Elisa AlessandrelliCenter for Advanced Studies and Technology, G. d'Annunzio University, 66100 Chieti, Italy.
Stefania NotarangeloCenter for Advanced Studies and Technology, G. d'Annunzio University, 66100 Chieti, Italy.
Liborio StuppiaCenter for Advanced Studies and Technology, G. d'Annunzio University, 66100 Chieti, Italy.
Ester VitacolonnaDepartment of Medicine and Aging, School of Medicine and Health Sciences, G. d'Annunzio University, 66100 Chieti, Italy.ORCID 0000-0003-1756-661X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human circadian system has a period of approximately 24 h and studies on the consequences of "chornodisruption" have greatly expanded. Lifestyle and environmental factors of modern societies (i.e., artificial lighting, jetlag, shift work, and around-the-clock access to energy-dense food) can induce disruptions of the circadian system and thereby adversely affect individual health. Growing evidence demonstrates a complex reciprocal relationship between metabolism and the circadian system, in which perturbations in one system affect the other one. From a nutritional genomics perspective, genetic variants in clock genes can both influence metabolic health and modify the individual response to diet. Moreover, an interplay between the circadian rhythm, gut microbiome, and epigenome has been demonstrated, with the diet in turn able to modulate this complex link suggesting a remarkable plasticity of the underlying mechanisms. In this view, the study of the impact of the timing of eating by matching elements from nutritional research with chrono-biology, that is, chrono-nutrition, could have significant implications for personalized nutrition in terms of reducing the prevalence and burden of chronic diseases. This review provides an overview of the current evidence on the interactions between the circadian system and nutrition, highlighting how this link could in turn influence the epigenome and microbiome. In addition, possible nutritional strategies to manage circadian-aligned feeding are suggested.

Indexed as

Circadian ClocksCircadian RhythmDietHumansLife StyleNutrigenomicsNutritional Statuschronodisruptionclock genesepigeneticsgene–diet interactiongut microbiomenutrigeneticspersonalized nutrition

Identifiers

PMID36768893
PMCPMC9916946

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.