ReviewInternational journal of molecular sciences2023
Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Flupentixol/melitracen for epigastric pain syndrome in female patients with abnormal urinalysis and therapeutic insights into the brain-bladder axis.Scientific reports · 2025Trial
- Pathophysiology and multi-target prevention strategies for cyclophosphamide-induced bladder injury.iScience · 2026Review
- Oxidative Balance Score and Overactive Bladder Risk in US Adults: A Negative Dose-Response Association from NHANES 2005-2018.International urogynecology journal · 2026Article
- Comparative study between female patients with functional dyspepsia accompanied by abnormal urinalysis and those with urinary tract infections: a retrospective case-control study.Scientific reports · 2026Article
- Impact of preoperative antidepressant use on surgical and functional outcomes of robot assisted radical prostatectomy.Scientific reports · 2025Article
- Prevalence and Phenotype of Lower Urinary Tract Symptoms in Fibromyalgia: A Retrospective Observational Study at a Single Tertiary Medical Center.Journal of clinical medicine · 2025Article
- Article
- Adverse childhood experiences and lower urinary tract symptoms in adolescence: the mediating effect of inflammation.International journal of epidemiology · 2025Article
- Predictive role of neutrophil-percentage-albumin ratio (NPAR) in overactive bladder (OAB) in adults in the United States: a cross-sectional study.Journal of health, population, and nutrition · 2025Article
- The association between urinary cadmium exposure levels and overactive bladder syndrome in the U.S. adults from NHANES database.Scientific reports · 2025Article
- Should We Be Treating Affective Symptoms, Like Anxiety and Depression Which May Be Related to LUTD in Patients With OAB? ICI-RS 2024.Neurourology and urodynamics · 2025Review
- Exploring the Association Between Overactive Bladder (OAB) and Cognitive decline: mediation by depression in elderly adults, a NHANES weighted analysis.Scientific reports · 2025Article
- Bidirectional relationships between depression, anxiety and urinary symptoms in women: A prospective cohort study.Journal of affective disorders · 2025Article
- Association Between Subclinical Depression and the Severity of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia and the Mediating Effect of Sleep Quality in Elderly Chinese Men.Neuropsychiatric disease and treatment · 2025Article
- Association between weight-adjusted waist index and overactive bladder syndrome among adult women in the United States: a cross-sectional study.BMC women's health · 2024Article
- Specialized pro-resolution mediators in the bladder: effects of resolvin E1 on diabetic bladder dysfunction in the type 1 diabetic male Akita mouse model.BMC urology · 2024Article
- Lactobacillus-Polydopamine System for Targeted Drug Delivery in Overactive Bladder: Evidence from Bladder Cell Spheroids, Rat Models, and Urinary Microbiome Profiling.International journal of nanomedicine · 2024Article
- The Burden of Urinary Tract Infections on Quality of Life and Healthcare in Patients with Interstitial Cystitis.Healthcare (Basel, Switzerland) · 2023Article
- Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions.Molecular psychiatry · 2023Review
- Uroprotective and pain-relieving effect of dietary supplementation with micronized palmitoyl-glucosamine and hesperidin in a chronic model of cyclophosphamide-induced cystitis.Frontiers in veterinary science · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Anecdotal evidence has long suggested that patients with lower urinary tract symptoms (LUTS) develop mood disorders, such as depression and anxiety, at a higher rate than the general population and recent prospective studies have confirmed this link. Breakthroughs in our understanding of the diseases underlying LUTS have shown that many have a substantial inflammatory component and great strides have been made recently in our understanding of how this inflammation is triggered. Meanwhile, studies on mood disorders have found that many are associated with central neuroinflammation, most notably in the hippocampus. Excitingly, work on other diseases characterized by peripheral inflammation has shown that they can trigger central neuroinflammation and mood disorders. In this review, we discuss the current evidence tying LUTS to mood disorders, its possible bidirectionally, and inflammation as a common mechanism. We also review modern theories of inflammation and depression. Finally, we discuss exciting new animal studies that directly tie two bladder conditions characterized by extensive bladder inflammation (cyclophosphamide-induced hemorrhagic cystitis and bladder outlet obstruction) to neuroinflammation and depression. We conclude with a discussion of possible mechanisms by which peripheral inflammation is translated into central neuroinflammation with the resulting psychiatric concerns.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.