Evidence map›Paper›PMID 36769158›Full record

ArticleInternational journal of molecular sciences2023

Insights into the Peritumoural Brain Zone of Glioblastoma:

Martina Giambra, Andrea Di Cristofori, Donatella Conconi, Matilde Marzorati, Serena Redaelli, Melissa Zambuto, Alessandra Rocca, Louis Roumy, Giorgio Carrabba, Marialuisa Lavitrano and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. AhRR and PPP1R3C: Potential Prognostic Biomarkers for Serous Ovarian Cancer.International journal of molecular sciences · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Martina GiambraSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-4980-8743
Andrea Di CristoforiPhD Program in Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-6148-1894
Donatella ConconiSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-5665-9558
Matilde MarzoratiSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Serena RedaelliSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-0415-4085
Melissa ZambutoSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Alessandra RoccaSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Louis RoumySchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Giorgio CarrabbaSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-0170-0653
Marialuisa LavitranoSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-4852-1318
Gaia RoversiSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-8515-0187
Carlo GiussaniSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Angela BentivegnaSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-7535-846X

Funding

Italian ministry MIUR PRIN 2017University of Milano-Bicocca 2021-ATE-0404
6 · The paper itself

Abstract

Despite the efforts made in recent decades, glioblastoma is still the deadliest primary brain cancer without cure. The potential role in tumour maintenance and progression of the peritumoural brain zone (PBZ), the apparently normal area surrounding the tumour, has emerged. Little is known about this area due to a lack of common definition and due to difficult sampling related to the functional role of peritumoural healthy brain. The aim of this work was to better characterize the PBZ and to identify genes that may have role in its malignant transformation. Starting from our previous study on the comparison of the genomic profiles of matched tumour core and PBZ biopsies, we selected

Indexed as

Brain NeoplasmsGlioblastomaGliomaBrainCyclin-Dependent Kinase 4Gene Expression ProfilingHumansCDK4 protein, humanCyclin-Dependent Kinase 4CDK4EXT2glioblastomamalignant transformationperitumoural brain zone

Identifiers

PMID36769158
PMCPMC9917451

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.