ReviewInternational journal of molecular sciences2023
Vitamin D Deficiency: An Underestimated Factor in Sepsis?
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Serum 25-hydroxyvitamin D levels are associated with thyroid diseases: A systematic review and meta-analysis.Medicine · 2026Pooled it
- A systematic review and meta-analysis of Vitamin D status and clinical outcomes in critically ill neonates.Frontiers in nutrition · 2026Pooled it
- The Modulatory Role of Vitamin D in the Molecular Mechanisms of Sepsis and Infections with Focus on Viral Pathogenesis: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Impact of Vitamin D3 Supplementation on 28-Day ICU Mortality in Sepsis Patients: A Retrospective Study with Propensity Score Matching.Pathogens (Basel, Switzerland) · 2026Article
- The Role of Vitamins in Sepsis: A Narrative Review.Nutrients · 2025Review
- Fat-soluble vitamins as biomarkers of nutritional status and their relation with complications in polytrauma patients.Nutrition and health · 2025Observational
- Serial Changes in Vitamin D Status in Patients During Severe Acute Respiratory Distress Syndrome and Extracorporeal Membrane Oxygenation.Medicina (Kaunas, Lithuania) · 2025Article
- Impact of serum calcium levels on the occurrence of sepsis and prognosis in hospitalized patients with concomitant psoriasis: a retrospective study based on the MIMIC-IV database.Frontiers in immunology · 2025Article
- Impact of Iron Profile and Vitamin D Levels on Clinical Outcomes in Patients with Sepsis and Septic Shock: A Cross-sectional Analysis at a Tertiary Care Center.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Intermittent High-Dose Vitamin D3 Administration in Neonates with Multiple Comorbidities and Vitamin D Insufficiency.Children (Basel, Switzerland) · 2024Article
- Review
- Article
- Vitamin D-Binding Protein and the Role of its Gene Polymorphisms in the Mortality of Sepsis Patients.Acta medica academica · 2023Observational
- Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function.Nutrients · 2023Review
- The Role of Vitamin D Binding Protein and Vitamin D Level in Mortality of Sepsis Patients.Reports of biochemistry & molecular biology · 2023Article
- Vitamin D and Vitamin D Binding Protein in Health and Disease 2.0.International journal of molecular sciences · 2023Article
- Association of serum 25-hydroxyvitamin D concentrations with all-cause mortality among individuals with kidney stone disease: the NHANES database prospective cohort study.Frontiers in endocrinology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D is an important immune modulator that is linked to infection susceptibility. It has been suggested that vitamin D deficiency plays a role in sepsis and septic shock because vitamin-D-related pathways are associated with various immunological, endocrine, and endothelial functions. Previous research has yielded inconclusive results regarding the link between mortality and vitamin D deficiency in sepsis patients. In patients with sepsis and severe vitamin D deficiency, an adequate vitamin D concentration may reduce mortality. Randomized controlled trials to assess the influence of vitamin D supplementation on clinical outcomes in sepsis patients with vitamin D deficiency are uncommon. We will provide an overview of the current knowledge about the relationship between vitamin D and sepsis in this review, as well as consider the potential value of vitamin D supplementation in this situation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.