Evidence map›Paper›PMID 36769293›Full record

ReviewInternational journal of molecular sciences2023

Insights of Endocytosis Signaling in Health and Disease.

Chandramani Pathak, Foram U Vaidya, Bhargav N Waghela, Pradip Kumar Jaiswara, Vishal Kumar Gupta, Ajay Kumar, Barani Kumar Rajendran, Kishu Ranjan

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Targeted nanoliposomal nutrient delivery for human health.World journal of gastrointestinal pharmacology and therapeutics · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chandramani PathakSchool of Biomedical Sciences, MGM Institute of Health Sciences, Navi Mumbai 410 209, Maharashtra, India.ORCID 0000-0002-9389-8096
Foram U VaidyaGujarat Biotechnology Research Centre, Gandhinagar 382011, Gujarat, India.
Bhargav N WaghelaDepartment of Microbiology, Atmiya University, Rajkot 360005, Gujarat, India.
Pradip Kumar JaiswaraDepartment of Zoology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.
Vishal Kumar GuptaDepartment of Zoology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.
Ajay KumarDepartment of Zoology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.
Barani Kumar RajendranDepartment of Pathology, School of Medicine, Yale University, New Haven, CT 06511, USA.ORCID 0000-0001-9675-7718
Kishu RanjanDepartment of Pathology, School of Medicine, Yale University, New Haven, CT 06511, USA.ORCID 0000-0003-1256-181X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocytosis in mammalian cells is a fundamental cellular machinery that regulates vital physiological processes, such as the absorption of metabolites, release of neurotransmitters, uptake of hormone cellular defense, and delivery of biomolecules across the plasma membrane. A remarkable characteristic of the endocytic machinery is the sequential assembly of the complex proteins at the plasma membrane, followed by internalization and fusion of various biomolecules to different cellular compartments. In all eukaryotic cells, functional characterization of endocytic pathways is based on dynamics of the protein complex and signal transduction modules. To coordinate the assembly and functions of the numerous parts of the endocytic machinery, the endocytic proteins interact significantly within and between the modules. Clathrin-dependent and -independent endocytosis, caveolar pathway, and receptor mediated endocytosis have been attributed to a greater variety of physiological and pathophysiological roles such as, autophagy, metabolism, cell division, apoptosis, cellular defense, and intestinal permeabilization. Notably, any defect or alteration in the endocytic machinery results in the development of pathological consequences associated with human diseases such as cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. In this review, an in-depth endeavor has been made to illustrate the process of endocytosis, and associated mechanisms describing pathological manifestation associated with dysregulated endocytosis machinery.

Indexed as

CaveolaeEndocytosisAnimalsBiological TransportCell MembraneHumansMammalsSignal Transductionchronic diseasesendocytosisphagocytosispinocytosisreceptor endocytosis signaling

Identifiers

PMID36769293
PMCPMC9918140

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.