Evidence mapPaperPMID 36769560Full record

ReviewJournal of clinical medicine2023

Diabetic Retinopathy: Soluble and Imaging Ocular Biomarkers.

Mariantonia Ferrara, Alessandra Loda, Giulia Coco, Piergiacomo Grassi, Silvia Cestaro, Sara Rezzola, Vito Romano, Francesco Semeraro

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Biomaterials for biomarker imaging and detection.Journal of advanced research · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mariantonia FerraraManchester Royal Eye Hospital, Oxford Road, Manchester M13 9WL, UK.
Alessandra LodaDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
Giulia CocoDepartment of Clinical Science and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-2410-6366
Piergiacomo GrassiNorthern Care Alliance NHS Foundation Trust, Whitehall St, Rochdale OL12 0NB, UK.
Silvia CestaroEye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-6038-4515
Sara RezzolaDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.ORCID 0000-0003-1193-8929
Vito RomanoEye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-5148-7643
Francesco SemeraroEye Clinic, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-2275-4917

Funding

Fondazione Cariplo 2021-1563
6 · The paper itself

Abstract

Diabetic retinopathy (DR), the most common microvascular complication of diabetes mellitus, represents the leading cause of acquired blindness in the working-age population. Due to the potential absence of symptoms in the early stages of the disease, the identification of clinical biomarkers can have a crucial role in the early diagnosis of DR as well as for the detection of prognostic factors. In particular, imaging techniques are fundamental tools for screening, diagnosis, classification, monitoring, treatment planning and prognostic assessment in DR. In this context, the identification of ocular and systemic biomarkers is crucial to facilitate the risk stratification of diabetic patients; moreover, reliable biomarkers could provide prognostic information on disease progression as well as assist in predicting a patient's response to therapy. In this context, this review aimed to provide an updated and comprehensive overview of the soluble and anatomical biomarkers associated with DR.

Indexed as

confocal microscopycorneal endothelial cell countdiabetic retinopathyfluorescein angiographyocular biomarkers diabetic retinopathyoptical coherence tomographyoptical coherence tomography angiographyserum biomarkers diabetic retinopathyultra-widefield fundus photography

Identifiers

PMID36769560
PMCPMC9917666

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.