ReviewMolecules (Basel, Switzerland)2023
Anti-Melanogenic Potential of Natural and Synthetic Substances: Application in Zebrafish Model.
Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Engineered platforms for melanogenesis research: Bridging synthetic biology, bioengineering, and biomimetics.Bioengineering & translational medicine · 2026Review
- Article
- Tyrosinase Inhibitors With Enhanced Potency in Mammalian and Vertebrate Models, N-(2-Mercaptoethyl)benzamide Derivatives: Design, Synthesis, and Evaluation.Chemical biology & drug design · 2026Article
- Kojic Acid as a Natural Hypopigmenting Agent: Biological Activities, Delivery Challenges, and Nanotechnology-Based Strategies.Pharmaceutics · 2026Review
- Bioactive Lipid Mediator Resolvin D5 Suppresses Melanogenesis in α-MSH-Stimulated B16F10 Cells via ROS-Associated p38/β-Catenin/MITF Regulation.Journal of microbiology and biotechnology · 2026Article
- Combining bioinformatics prediction with experimental validation to explore the ameliorative effect ofMolecular medicine reports · 2026Article
- Article
- Evaluation of Polysaccharides Safety and Potential Bioactivities Using Zebrafish: A Review.Chemistry & biodiversity · 2026Review
- A transcriptome analysis revealing the molecular mechanism of light intensity-driven color variation in the skin of Chinese giant salamander (Andrias davidianus).BMC genomics · 2026Article
- Biological Evaluation and Molecular Docking Study of Ferrociphenol as an Antimelanogenic Agent.Biochemistry research international · 2026Article
- 2,5-Dihydroxyphenylethanone: an anti-melanogenic bioactive compound isolated fromJournal of enzyme inhibition and medicinal chemistry · 2025Article
- Anti-melanogenic effects of Medicago sativa seed extracts on melanocytes.International journal of cosmetic science · 2025Article
- Sustainable repeated-batch fermentation of immobilized Ganoderma formosanum for enhanced production of anti-melanogenic bioactive compounds.NPJ science of food · 2025Article
- Article
- Harnessing Azelaic Acid for Acute Myeloid Leukemia Treatment: A Novel Approach to Overcoming Chemoresistance and Improving Outcomes.International journal of molecular sciences · 2025Review
- Design and Synthesis of Novel 6-(Substituted phenyl)-[1,3]dioxolo[4',5':4,5]benzo[1,2-Molecules (Basel, Switzerland) · 2025Article
- Toxicity and Anti-inflammatory Effects ofAnti-inflammatory & anti-allergy agents in medicinal chemistry · 2025Article
- Aromatic compounds and organic acids identified from Ganoderma formosanum exhibit synergistic anti-melanogenic effects.Journal of food and drug analysis · 2024Article
- Toxicity and Metabolomic Dysfunction Invoked by Febrifugin, a Harmful Component of Edible Nut ofInternational journal of molecular sciences · 2024Article
- Mechanism, Formulation, and Efficacy Evaluation of Natural Products for Skin Pigmentation Treatment.Pharmaceutics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme in the process of pigmentation through melanin is tyrosinase, which catalyzes the first and only limiting step in melanogenesis. Since the discovery of its methanogenic properties, tyrosinase has been the focus of research related to the anti-melanogenesis. In addition to developing more effective and commercially safe inhibitors, more studies are required to better understand the mechanisms involved in the skin depigmentation process. However, in vivo assays are necessary to develop and validate new drugs or molecules for this purpose, and to accomplish this, zebrafish has been identified as a model organism for in vivo application. In addition, such model would allow tracking and studying the depigmenting activity of many bioactive compounds, important to genetics, medicinal chemistry and even the cosmetic industry. Studies have shown the similarity between human and zebrafish genomes, encouraging their use as a model to understand the mechanism of action of a tested compound. Interestingly, zebrafish skin shares many similarities with human skin, suggesting that this model organism is suitable for studying melanogenesis inhibitors. Accordingly, several bioactive compounds reported herein for this model are compared in terms of their molecular structure and possible mode of action in zebrafish embryos. In particular, this article described the main metabolites of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.