ArticleMolecules (Basel, Switzerland)2023
Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3
Sida Shen, Arseniy Butrin, Brett A Beaupre, Glaucio M Ferreira, Peter F Doubleday, Daniel H Grass, Wei Zhu, Neil L Kelleher, Graham R Moran, Dali Liu and 1 more
Open access · goldAbstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors at 3 institutions in 2 countries.
Sida ShenDepartment of Chemistry and Center for Developmental Therapeutics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0295-2545 Arseniy ButrinDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660, USA.
Brett A BeaupreDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660, USA.
Glaucio M FerreiraDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil.ORCID 0000-0002-1952-9428 Peter F DoubledayDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-1784-1282 Daniel H GrassDepartment of Chemistry and Center for Developmental Therapeutics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-5011-4108 Wei ZhuDepartment of Chemistry and Center for Developmental Therapeutics, Northwestern University, Evanston, IL 60208, USA.
Neil L KelleherDepartment of Chemistry and Center for Developmental Therapeutics, Northwestern University, Evanston, IL 60208, USA.
Graham R MoranDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660, USA.
Dali LiuDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660, USA.ORCID 0000-0002-7587-703X Richard B SilvermanDepartment of Chemistry and Center for Developmental Therapeutics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-9034-1084 Northwestern University · USLoyola University Chicago · USUniversidade de São Paulo · BR
Funding
The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Jonathan V. Sweedler · 2004 to 2026
$24.9MNew Inactivators of GABA Aminotransferase for Addiction and EpilepsyR01DA030604 · NIDA · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 2011 to 2020
$4.0MOrnithine Aminotransferase Inactivation, a New Approach for Treatment of CancersR01CA260250 · NCI · NORTHWESTERN UNIVERSITY · PI RICHARD B SILVERMAN · 2021 to 2026
$2.3MNCI NIH HHS R01 CA260250NIDA NIH HHS P30 DA018310NIDA NIH HHS R01 DA030604NIH HHS CA260250NIH HHS DA030604NIH HHS P30 DA018310
6 · The paper itselfAbstract
Ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), and we previously showed that inactivation of OAT inhibits the growth of HCC. Recently, we found that (3
Indexed as
Carcinoma, HepatocellularLiver NeoplasmsAmino AcidsCarboxylic AcidsEnzyme Inhibitorsgamma-Aminobutyric AcidHumansOrnithineOrnithine-Oxo-Acid TransaminaseAmino AcidsCarboxylic AcidsEnzyme Inhibitorsgamma-Aminobutyric AcidOrnithineOrnithine-Oxo-Acid Transaminaseaminotransferasecyclopenteneenaminemechanism-based inactivatorsmechanistic studies
Identifiers
PMID36770800
PMCPMC9921285
OpenAlexW4317738199
What Socratic holds
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LicenceCC BY
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