Evidence map›Paper›PMID 36775331›Full record

ArticleJournal of atherosclerosis and thrombosis2023

Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya and 10 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Relationship between Vascular Tortuosity Rate and Atherosclerotic Risk Factors in Patients with Carotid Artery Stenosis.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
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  5. Review
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  7. Association Between Carotid Intima-Media Thickness and Novel Lipid Parameters in Hypertensive Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Masato TakaseGraduate School of Medicine, Tohoku University.
Naoki NakayaGraduate School of Medicine, Tohoku University.
Tomohiro NakamuraGraduate School of Medicine, Tohoku University.
Mana KogureGraduate School of Medicine, Tohoku University.
Rieko HatanakaGraduate School of Medicine, Tohoku University.
Kumi NakayaGraduate School of Medicine, Tohoku University.
Ippei ChibaGraduate School of Medicine, Tohoku University.
Ikumi KannoGraduate School of Medicine, Tohoku University.
Kotaro NochiokaGraduate School of Medicine, Tohoku University.
Naho TsuchiyaGraduate School of Medicine, Tohoku University.
Takumi HirataInstitute for Clinical and Translational Science, Nara Medical University.
Yohei HamanakaTohoku Medical Megabank Organization, Tohoku University.
Junichi SugawaraGraduate School of Medicine, Tohoku University.
Tomoko KobayashiGraduate School of Medicine, Tohoku University.
Nobuo FuseTohoku Medical Megabank Organization, Tohoku University.
Akira UrunoTohoku Medical Megabank Organization, Tohoku University.
Eiichi N KodamaTohoku Medical Megabank Organization, Tohoku University.
Shinichi KuriyamaGraduate School of Medicine, Tohoku University.
Ichiro TsujiGraduate School of Medicine, Tohoku University.
Atsushi HozawaGraduate School of Medicine, Tohoku University.
Tohoku University · JPTohoku Medical Megabank Organization · JPNara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimWe examined the association between the carotid intima medica thickness (cIMT) and risk factors for atherosclerosis based on the Japan Atherosclerosis Society 2022 Atherosclerosis Prevention Guideline.

methodsUsing data from the Tohoku Medical Megabank Community-based Cohort Study, we performed a cross-sectional study that enrolled 13,366 participants (age ≥ 20 years) with an analysis of covariance to assess associations between cIMT and risk factors for atherosclerosis. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. Analysis was conducted in the model adjusted for age, sex, smoking status, drinking status, body mass index (BMI), systolic blood pressure (SBP), glycated hemoglobin (HbA1c), high-density lipoprotein-cholesterol (HDL-C), non-high-density lipoprotein-cholesterol (non-HDL-C), and height.

resultsIn this study cohort, the average age and cIMT were 57.3 (13.8) years and 0.61 (0.13) mm, respectively, which included 3,988 males (29.8%). Males had a higher cIMT than did the females. Age, height, BMI, SBP, HbA1c, and non-HDL-C were positively associated with cIMT. HDL-C was inversely associated with cIMT. Compared with never drinkers, current drinkers (≥ 46.0 g/day) had a significantly decreased cIMT.

conclusionsThe cIMT was associated with atherosclerosis risk factors including age, sex, BMI, SBP, HbA1c, non-HDL-C, and HDL-C, and adequate control of risks in high-risk individuals might be required to prevent atherosclerotic cardiovascular diseases.

Indexed as

AtherosclerosisCarotid Intima-Media ThicknessAdultAgedCarotid ArteriesCholesterolCholesterol, HDLCohort StudiesCross-Sectional StudiesFemaleGlycated HemoglobinHumansMaleMiddle AgedRisk FactorsYoung AdultCholesterolCholesterol, HDLGlycated HemoglobinAtherosclerosisCarotid intima media thicknessEpidemiologyRisk factor

Identifiers

PMID36775331
PMCPMC10564640
OpenAlexW4320169293

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.