Evidence map›Paper›PMID 36776398›Full record

ArticleFrontiers in immunology2022

Vanadium exposure exacerbates allergic airway inflammation and remodeling through triggering reactive oxidative stress.

Wei Tu, Xiaojun Xiao, Jiahua Lu, Xiaoyu Liu, Eryi Wang, Ruyi Yuan, Rongjun Wan, Yingchun Shen, Damo Xu, Pingchang Yang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
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  5. Review
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  8. Epithelial sensing in allergic disease.Current opinion in immunology · 2024
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  9. Multifaceted roles of mitochondria in asthma.Cell biology and toxicology · 2024
    Review
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  13. Integrating Pt nanoparticles with 3D CuFrontiers in immunology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Wei TuDepartment of Respiratory & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Xiaojun XiaoThe State Key Laboratory of Respiratory Disease for Allergy, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Jiahua LuThe State Key Laboratory of Respiratory Disease for Allergy, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Xiaoyu LiuThe State Key Laboratory of Respiratory Disease for Allergy, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Eryi WangDepartment of Respiratory & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Ruyi YuanThe State Key Laboratory of Respiratory Disease for Allergy, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Rongjun WanJohns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Yingchun ShenJohns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Damo XuDepartment of Respiratory & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Pingchang YangDepartment of Respiratory & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Miao GongDepartment of Respiratory & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Peisong GaoJohns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Shau-Ku HuangDepartment of Respiratory & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Shenzhen Third People’s Hospital · CNShenzhen University · CNCentral South University · CNJohns Hopkins Medicine · USJohns Hopkins University · US

Funding

Environmental Pollutants Potentiate Allergic Inflammation via Functional Axis of Aryl hydrocarbon Receptor, ROS, and CaMKII in AsthmaR01AI141642 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2019 to 2024
$2.9M
Functional role of miR-511-3p in allergic asthma and its underlying mechanismsR01AI153331 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Peisong Gao · 2021 to 2026
$2.7M
NIAID NIH HHS R01 AI141642NIAID NIH HHS R01 AI153331
6 · The paper itself

Abstract

Background: Metal components of environmental PM2.5 are associated with the exacerbation of allergic diseases like asthma. In our recent hospital-based population study, exposure to vanadium is shown to pose a significant risk for current asthma, but the causal relationship and its underlying molecular mechanisms remain unclear. Objective: We sought to determine whether vanadium co-exposure can aggravate house dust mite (HDM)-induced allergic airway inflammation and remodeling, as well as investigate its related mechanisms. Methods: Asthma mouse model was generated by using either vanadium pentoxide (V Results: Compared to HDM alone, V Conclusions: Our findings suggest that vanadium co-exposure exacerbates epithelial ROS generation that contribute to increased allergic airway inflammation and remodeling.

Indexed as

AsthmaVanadiumAirway RemodelingAnimalsAntioxidantsCytokinesDermatophagoides pteronyssinusHumansInflammationMiceOxidative StressPyroglyphidaeReactive Oxygen SpeciesAntioxidantsCytokinesReactive Oxygen SpeciesVanadiumairway inflammationairway remodelinghouse dust miteROSvanadiumvitamin D3

Identifiers

PMID36776398
PMCPMC9912158
OpenAlexW4318217677

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.