Evidence map›Paper›PMID 36778671›Full record

ArticleJournal of medical imaging (Bellingham, Wash.)2023

Measurement of enhanced vasa vasorum density in a porcine carotid model using photon counting detector CT.

Jeffrey F Marsh, Andrew J Vercnocke, Kishore Rajendran, Shengzhen Tao, Jill L Anderson, Erik L Ritman, Shuai Leng, Cynthia H McCollough

Abstract read
In one paragraph

Article in Journal of medical imaging (Bellingham, Wash.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Journal of medical imaging (Bellingham, Wash.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jeffrey F MarshMayo Clinic, Department of Radiology, Rochester, Minnesota, United States.
Andrew J VercnockeMayo Clinic, Department of Radiology, Rochester, Minnesota, United States.
Kishore RajendranMayo Clinic, Department of Radiology, Rochester, Minnesota, United States.ORCID https://orcid.org/0000-0002-8314-3642
Shengzhen TaoMayo Clinic, Department of Radiology, Rochester, Minnesota, United States.
Jill L AndersonMayo Clinic, Department of Radiology, Rochester, Minnesota, United States.
Erik L RitmanMayo Clinic, Department of Physiology and Biomedical Engineering, Rochester, Minnesota, United States.
Shuai LengMayo Clinic, Department of Radiology, Rochester, Minnesota, United States.ORCID https://orcid.org/0000-0002-6453-9481
Cynthia H McColloughMayo Clinic, Department of Radiology, Rochester, Minnesota, United States.ORCID https://orcid.org/0000-0002-5346-332X

Funding

Photon-Counting Spectral CT to Reduce Dose and Detect Early Vascular DiseaseR01EB016966 · NIBIB · MAYO CLINIC ROCHESTER · PI MCCOLLOUGH, CYNTHIA H · 2013 to 2017
$5.1M
Comprehensive characterization of coronary atherosclerotic disease using photon-counting-detector dual-source CT and its impact on patient managementR01EB028590 · NIBIB · MAYO CLINIC ROCHESTER · PI LENG, SHUAI, MCCOLLOUGH, CYNTHIA H · 2020 to 2023
$2.6M
EXTRAMURAL RES FACIL IMPROVEMENT PROG: POLYCYSTIC KIDNEY DISEASE, RENAL STUDIES,C06RR018898 · NCRR · MAYO CLINIC · PI BURNETT, JOHN C · 2004 to 2004
$2.3M
NCRR NIH HHS C06 RR018898NIBIB NIH HHS R01 EB016966NIBIB NIH HHS R01 EB028590
6 · The paper itself

Abstract

Purpose: The onset of atherosclerosis is preceded by changes in blood perfusion within the arterial wall due to localized proliferation of the vasa vasorum. The purpose of this study was to quantify these changes in spatial density of the vasa vasorum using a research whole-body photon-counting detector CT (PCD-CT) scanner and a porcine model. Approach: Vasa vasorum angiogenesis was stimulated in the left carotid artery wall of anesthetized pigs ( Results: The greatest arterial wall enhancement was observed following contrast recirculation. The wall enhancement measurements made over these time points revealed that the enhancement was greater in the injured artery for 13/16 scanned arterial regions. Using an exact Wilcoxon-signed rank test, a significantly increased enhancement ratio was found in injured arteries compared with control arteries ( Conclusions: Whole-body PCD-CT scanners can be used to detect and quantify the increased perfusion occurring within the porcine carotid arterial wall resulting from an increased density of vasa vasorum.

Indexed as

arterial wall perfusionatherosclerosiscomputed tomographyintravascular contrast agentphoton counting detectorvasa vasorum

Identifiers

PMID36778671
PMCPMC9900679

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.