ReviewFrontiers in neurology2023
Opportunities and barriers to translating the hibernation phenotype for neurocritical care.
Review in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Using Organoids to Unlock the Potential of Human Torpor for Spaceflight.Current stem cell reports · 2026Article
- Serotype-dependent differences in AAV cellular transduction rates in the hypothalamus of Arctic ground squirrels.Journal of neuroscience methods · 2026Article
- Effect of post-weaning diet on hibernation occurrence in Syrian hamsters.Experimental animals · 2026Article
- Serotype-dependent differences in AAV cellular transduction rates in the hypothalamus of Arctic ground squirrels.bioRxiv : the preprint server for biology · 2026Article
- The poikilothermic hypothesis of sepsis.Critical care (London, England) · 2026Review
- Article
- Hibernation-Inspired Innovations in Biomedicine: Addressing Aging, Chronic Diseases, and Critical Care.Canadian journal of zoology · 2026Article
- Intestinal bacteria trigger a hibernation-like state in homotherms via the gut-brain axis.NPJ biofilms and microbiomes · 2025Article
- Review
- Conserved lipid metabolic reprogramming confers hypoxic and aging resilience.bioRxiv : the preprint server for biology · 2025Article
- Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus.Science (New York, N.Y.) · 2025Article
- Thermomechanical properties of bat and human red blood cells-Implications for hibernation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- NExperimental neurology · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Targeted temperature management (TTM) is standard of care for neonatal hypoxic ischemic encephalopathy (HIE). Prevention of fever, not excluding cooling core body temperature to 33°C, is standard of care for brain injury post cardiac arrest. Although TTM is beneficial, HIE and cardiac arrest still carry significant risk of death and severe disability. Mammalian hibernation is a gold standard of neuroprotective metabolic suppression, that if better understood might make TTM more accessible, improve efficacy of TTM and identify adjunctive therapies to protect and regenerate neurons after hypoxic ischemia brain injury. Hibernating species tolerate cerebral ischemia/reperfusion better than humans and better than other models of cerebral ischemia tolerance. Such tolerance limits risk of transitions into and out of hibernation torpor and suggests that a barrier to translate hibernation torpor may be human vulnerability to these transitions. At the same time, understanding how hibernating mammals protect their brains is an opportunity to identify adjunctive therapies for TTM. Here we summarize what is known about the hemodynamics of hibernation and how the hibernating brain resists injury to identify opportunities to translate these mechanisms for neurocritical care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.