ArticleAmerican journal of physiology. Cell physiology2023
Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth of murine enteroids.
James Sinnett-Smith, M Eugenia Torres-Marquez, Jen-Kuan Chang, Yuki Shimizu, Fang Hao, Martin G Martin, Enrique Rozengurt
Open access · greenAbstract read
In one paragraphArticle in American journal of physiology. Cell physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors at 1 institution in 1 country.
James Sinnett-SmithDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.ORCID 0000-0003-0074-7270 M Eugenia Torres-MarquezDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Jen-Kuan ChangDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Yuki ShimizuDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Fang HaoDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Martin G MartinDepartment of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Enrique RozengurtDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.ORCID 0000-0002-7838-9170 University of California, Los Angeles · US
Funding
COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8MTargeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2012 to 2016
$6.2MTargeting YAP with statins to prevent antibody-mediated transplant rejectionR21AI156592 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, ELAINE F, ROZENGURT, JUAN ENRIQUE · 2021 to 2022
$444kInteraction between Chronic Stress and Obesity in Pancreatic Cancer ProgressionR21CA258125 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EIBL, GUIDO ERWIN MICHAEL, ROZENGURT, JUAN ENRIQUE · 2022 to 2023
$397kBLRD VA I01 BX003801NCI NIH HHS P01 CA163200NCI NIH HHS R21 CA258125NIAID NIH HHS R21 AI156592NIDDK NIH HHS RC2 DK118640
6 · The paper itselfAbstract
We examined the impact of statins on protein kinase D (PKD) activation by G protein-coupled receptor (GPCR) agonists. Treatment of intestinal IEC-18 cells with cerivastatin inhibited PKD autophosphorylation at Ser
Indexed as
Hydroxymethylglutaryl-CoA Reductase InhibitorsAnimalsMiceMice, TransgenicPhosphorylationProtein Kinase CReceptors, G-Protein-CoupledSimvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsProtein Kinase Cprotein kinase DReceptors, G-Protein-CoupledSimvastatinangiotensin IIatorvastatincerivastatinCRT0066101intestinal IEC-18 cells
Identifiers
PMID36779664
PMCPMC10042602
OpenAlexW4320498408
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