Evidence map›Paper›PMID 36780662›Full record

ArticleAmerican journal of respiratory cell and molecular biology2023

Targeting ATP12A, a Nongastric Proton Pump α Subunit, for Idiopathic Pulmonary Fibrosis Treatment.

Mohamed Abdelgied, Katie Uhl, Oliver G Chen, Chad Schultz, Kaylie Tripp, Angela M Peraino, Shreya Paithankar, Bin Chen, Maximiliano Tamae Kakazu, Alicia Castillo Bahena and 10 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  5. Cystic fibrosis.Nature reviews. Disease primers · 2024
    Review
  6. Increased Expression of ATP12A in Small Airway Epithelia of Post-COVID-19 Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. ATP12A: Connecting Mucus and Fibrosis in Idiopathic Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Mohamed AbdelgiedDepartment of Pediatrics and Human Development and.
Katie UhlDepartment of Pediatrics and Human Development and.
Oliver G ChenDepartment of Pediatrics and Human Development and.
Chad SchultzDepartment of Pediatrics and Human Development and.
Kaylie TrippDepartment of Pediatrics and Human Development and.
Angela M PerainoDivision of Pulmonary and Critical Care Medicine.
Shreya PaithankarDepartment of Pediatrics and Human Development and.
Bin ChenDepartment of Pediatrics and Human Development and.
Maximiliano Tamae KakazuDepartment of Medicine, College of Human Medicine, Michigan State University, Grand Rapids, Michigan.
Alicia Castillo BahenaResearch and Development, and.
Tara E JagerRichard Devos Heart and Lung Transplant Program, Spectrum Health, Grand Rapids, Michigan.
Cameron LawsonRichard Devos Heart and Lung Transplant Program, Spectrum Health, Grand Rapids, Michigan.
Dave W CheslaResearch and Development, and.
Nikolay PestovDepartment of Physiology and Pharmacology and Center for Diabetes and Endocrine Research, College of Medicine, University of Toledo, Health Science Campus, Toledo, Ohio.
Nikolai N ModyanovDepartment of Physiology and Pharmacology and Center for Diabetes and Endocrine Research, College of Medicine, University of Toledo, Health Science Campus, Toledo, Ohio.
Jeremy ProkopDepartment of Pediatrics and Human Development and.
Richard R NeubigDepartment of Pharmacology and Toxicology and.
Bruce D UhalDepartment of Physiology, Michigan State University, East Lansing, Michigan; and.
Reda E GirgisDepartment of Medicine, College of Human Medicine, Michigan State University, Grand Rapids, Michigan.
Xiaopeng LiDepartment of Pediatrics and Human Development and.
Spectrum Health · USMichigan State University · USUniversity of Toledo · USPulmonary and Critical Care Associates · US

Funding

Role of disrupted ASL pH regulation in small airways in CF lung disease pathogenesisR01HL153165 · NHLBI · MICHIGAN STATE UNIVERSITY · PI LI, XIAOPENG · 2021 to 2024
$2.2M
NHLBI NIH HHS R01 HL153165
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a pathological condition of unknown etiology that results from injury to the lung and an ensuing fibrotic response that leads to the thickening of the alveolar walls and obliteration of the alveolar space. The pathogenesis is not clear, and there are currently no effective therapies for IPF. Small airway disease and mucus accumulation are prominent features in IPF lungs, similar to cystic fibrosis lung disease. The

Indexed as

Cystic FibrosisIdiopathic Pulmonary FibrosisAnimalsBleomycinFibrosisH(+)-K(+)-Exchanging ATPaseHumansLungMiceProton PumpsATP12A protein, humanBleomycinH(+)-K(+)-Exchanging ATPaseProton PumpsATP12Ableomycinproton pump blockerpulmonary fibrosissmall airways

Identifiers

PMID36780662
PMCPMC10257074
OpenAlexW4320482285

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.