ArticleNature immunology2023
Apolipoprotein C3 induces inflammasome activation only in its delipidated form.
Abstract readLetterComment
In one paragraph
Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Triglyceride-Rich Lipoprotein Metabolism and Cardiovascular Risk in Diabetes: Bedside to Bench to Bedside.Circulation research · 2026Review
- Kidney-Vascular Metabolic Crosstalk: Altered Lipoproteins in CKD.Circulation research · 2026Review
- Atherogenic apolipoprotein C-III may not be as bad as we thought.Journal of thrombosis and haemostasis : JTH · 2026Article
- Elevated levels of apolipoprotein C3 impair platelet function and reduce thrombosis.Journal of thrombosis and haemostasis : JTH · 2026Article
- ApoC-III inhibition: from regulatory approval to equitable implementation.Nature reviews. Cardiology · 2026Article
- An Elevated Serum Apolipoprotein C-III Concentration is Associated with the Risk of Coronary Heart Disease in a Japanese General Population. The Hidaka Cohort Study.Journal of atherosclerosis and thrombosis · 2026Article
- Article
- The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities.MedComm · 2026Review
- Integrative analysis of serum lipids and chronic gastritis: causal insights from mendelian randomization and experimental models.Lipids in health and disease · 2025Article
- Article
- Elevated apolipoprotein C3 heightens atherosclerosis risk by mediating arterial accumulation of free cholesterol and local inflammation in diabetes.Research square · 2025Article
- Decreased Serum Apolipoprotein CIII in the Acute Phase of Kawasaki Disease.Pediatric cardiology · 2025Article
- Subclassification of obesity for precision prediction of cardiometabolic diseases.Nature medicine · 2025Article
- Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation.Cardiovascular diabetology · 2025Article
- Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids.Journal of lipid research · 2025Article
- Elevated apolipoprotein C3 augments diabetic kidney disease and associated atherosclerosis in type 2 diabetes.JCI insight · 2024Article
- Apolipoprotein C3: form begets function.Journal of lipid research · 2024Review
- Quartet of APOCs and the Different Roles They Play in Diabetes.Arteriosclerosis, thrombosis, and vascular biology · 2023Review
- Article
- Inflammasomes and Atherosclerosis: a Mixed Picture.Circulation research · 2023Review
Corrections and comments
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Authors and funding
12 authors.
Cheng-Chieh HsuDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3423-7159
Baohai ShaoDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Jenny E KanterDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Yi HeDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Tomas VaisarDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Joseph L WitztumDepartment of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA.
Janet Snell-BergeonBarbara Davis Center for Diabetes, University of Colorado Denver, Aurora, CO, USA.
Gregory McInnesEmpirico Inc, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-8033-2499
Shannon BruseEmpirico Inc, San Diego, CA, USA.
Omri GottesmanEmpirico Inc, San Diego, CA, USA.
Adam E MullickIonis Pharmaceuticals, Carlsbad, CA, USA.ORCID http://orcid.org/0000-0003-4600-961X
Karin E BornfeldtDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA. kbornfeldt@medicine.washington.edu.ORCID http://orcid.org/0000-0001-9208-6523
Funding
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4MPILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4MTriglycerides, Diabetes and Cardiovascular DiseaseP01HL151328 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 2020 to 2026
$19.6MUniversity of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Maki Nakayama · 2020 to 2026
$10.8MIdentifying new strategies for prevention of cardiovascular complications of diabetesR35HL150754 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E · 2020 to 2025
$6.2MApolipoprotein C3-loading of apolipoprotein B100 lipoproteins and cardiovascular disease in patients with type 1 diabetesR01HL161829 · NHLBI · UNIVERSITY OF WASHINGTON · PI HEINECKE, JAY W · 2022 to 2025
$3.3MLipid-associated macrophages in diabetic kidney diseaseR01DK121756 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jenny E. Kanter · 2020 to 2026
$2.7MNHLBI NIH HHS P01 HL151328NHLBI NIH HHS R01 HL161829NHLBI NIH HHS R35 HL150754NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK121756
Abstract
PubMed holds no abstract for this paper.
Indexed as
InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinApolipoprotein C-IIIApolipoprotein C-IIIInflammasomesNLR Family, Pyrin Domain-Containing 3 Protein
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.