Evidence map›Paper›PMID 36785673›Full record

ArticleComputational and mathematical methods in medicine2023

Xiaoqing Wu, Wenping Lu, Chaojie Xu, Cuihong Jiang, Weixuan Zhang, Dongni Zhang, Shasha Cui, Zhili Zhuo, Yongjia Cui, Heting Mei and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Computational and mathematical methods in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Xiaoqing Wu *Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-9224-631X
Wenping LuDepartment of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-5589-1048
Chaojie Xu *The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan Province, China.ORCID https://orcid.org/0000-0001-9609-1848
Cuihong Jiang *Department of Oncology, Guang'anmen Hospital South Campus, China Academy of Chinese Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-1755-8073
Weixuan Zhang *Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0003-2424-9145
Dongni ZhangDepartment of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-9788-3249
Shasha CuiDepartment of Oncology, Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-5578-6774
Zhili ZhuoDepartment of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-7653-5197
Yongjia CuiDepartment of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-2139-6708
Heting MeiDepartment of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0003-0903-2554
Ya'nan WangDepartment of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-6618-2279
Chen LiDepartment of Biology, Chemistry, Pharmacy, Free University of Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-6895-2759
Chinese Academy of Medical Sciences & Peking Union Medical College · CNFifth Affiliated Hospital of Zhengzhou University · CNFreie Universität Berlin · DEShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ovarian cancer tends to metastasize to the omentum, which is an organ mainly composed of adipose tissue. Many studies have found that fatty acid metabolism is related to the occurrence and metastasis of cancers. Therefore, it is possible that fatty acid metabolism-related genes (FAMRG) affect the prognosis of ovarian cancer patients. Methods: First, profiles of ovarian cancer and normal ovarian tissue transcriptomes were acquired from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases. A LASSO regression predictive model was developed via the "glmnet" R package. The nomogram was created via the "regplot." Gene Set Variation Analysis (GSVA), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Ontology (GO) analyses were conducted to determine the FAMRGs' roles. The percentage of immunocyte infiltration was calculated via CIBERSORT. Using "pRRophetic," the sensitivity of eight regularly used medications and immunotherapy was anticipated. Results: 125 genes were determined as different expression genes (DEGs). Based on RXRA, ECI2, PTGIS, and ACACB, a prognostic model is created and the risk score is calculated. Analyses of univariate and multivariate regressions revealed that the risk score was a distinct prognostic factor (univariate: HR: 2.855, 95% CI: 1.756-4.739, Conclusion:

Indexed as

Ovarian NeoplasmsCisplatinCytochrome P-450 Enzyme SystemDodecenoyl-CoA IsomeraseDoxorubicinFatty AcidsFemaleHumansLipid MetabolismCisplatinCytochrome P-450 Enzyme SystemDodecenoyl-CoA IsomeraseDoxorubicinECI2 protein, humanFatty AcidsPTGIS protein, human

Identifiers

PMID36785673
PMCPMC9918844
OpenAlexW4318956433

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.