Evidence map›Paper›PMID 36788340›Full record

ArticleScientific reports2023

MSR1 is not required for obesity-associated inflammation and insulin resistance in mice.

Sierra A Nance, Lindsey Muir, Jennifer Delproprosto, Carey N Lumeng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sierra A NanceMolecular and Integrative Physiology, University of Michigan Medical School, 109 Zina Pitcher Place, 2057 BSRB, Ann Arbor, MI, 48109, USA.
Lindsey MuirComputational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.
Jennifer DelproprostoDepartment of Pediatrics, University of Michigan Medical School, 109 Zina Pitcher Place, 2057 BSRB, Ann Arbor, MI, 48109, USA.
Carey N LumengMolecular and Integrative Physiology, University of Michigan Medical School, 109 Zina Pitcher Place, 2057 BSRB, Ann Arbor, MI, 48109, USA. clumeng@umich.edu.ORCID 0000-0003-0303-6204
University of Michigan · US

Funding

Regulation of Adipose Tissue Inflammation By Antigen Presenting CellsR01DK090262 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, CAREY N · 2011 to 2024
$5.3M
The Role of Macrophage Scavenger Receptor 1 in Type 2 DiabetesF31DK122724 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NANCE, SIERRA A · 2019 to 2022
$140k
NIDDK NIH HHS F31 DK122724NIDDK NIH HHS F32 DK076313NIDDK NIH HHS R01 DK090262
6 · The paper itself

Abstract

Obesity induces a chronic inflammatory state associated with changes in adipose tissue macrophages (ATMs). Macrophage scavenger receptor 1 (MSR1) has been implicated in the regulation of adipose tissue inflammation and diabetes pathogenesis; however, reports have been mixed on the contribution of MSR1 in obesity and glucose intolerance. We observed increased MSR1 expression in VAT of obese diabetic individuals compared to non-diabetic and single nuclear RNA sequencing identified macrophage-specific expression of MSR1 in human adipose tissue. We examined male Msr1

Indexed as

Insulin ResistanceObesityScavenger Receptors, Class AAdipose TissueAnimalsFemaleInflammationInsulinMaleMiceMice, Inbred C57BLInsulinMsr1 protein, mouseScavenger Receptors, Class A

Identifiers

PMID36788340
PMCPMC9927046
OpenAlexW4320857341

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.