Evidence map›Paper›PMID 36788486›Full record

ArticleBMC nephrology2023

Use machine learning to help identify possible sarcopenia cases in maintenance hemodialysis patients.

Hualong Liao, Yujie Yang, Ying Zeng, Ying Qiu, Yang Chen, Linfang Zhu, Ping Fu, Fei Yan, Yu Chen, Huaihong Yuan

Erratum issuedAbstract read
In one paragraph

Article in BMC nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Hualong Liao *Department of Applied Mechanics, College of Architecture and Environment, Sichuan University, Chengdu, 610065, Sichuan, China.
Yujie Yang *Department of Nephrology, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, 610041, Sichuan, China.
Ying ZengDepartment of Nephrology, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, 610041, Sichuan, China.
Ying QiuDepartment of Nephrology, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, 610041, Sichuan, China.
Yang ChenDepartment of Nephrology, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, 610041, Sichuan, China.
Linfang ZhuDepartment of Nephrology, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, 610041, Sichuan, China.
Ping FuKidney Research Laboratory, Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
Fei YanChongqing Municipality Clinical Research Center for Geriatric Diseases, Chongqing University Three Gorges Hospital, School of Medicine, Chongqing University, Chongqing, 404000, China.
Yu ChenDepartment of Applied Mechanics, College of Architecture and Environment, Sichuan University, Chengdu, 610065, Sichuan, China. yu_chen@scu.edu.cn.
Huaihong YuanDepartment of Nephrology, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, 610041, Sichuan, China. yuanhuaihong@wchscu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaintenance hemodialysis (MHD) patients often suffer from sarcopenia, which is strongly associated with their long-term mortality. The diagnosis and treatment of sarcopenia, especially possible sarcopenia for MHD patients are of great importance. This study aims to use machine learning and medical data to develop two simple sarcopenia identification assistant tools for MHD patients and focuses on sex specificity.

methodsData were retrospectively collected from patients undergoing MHD and included patients' basic information, body measurement results and laboratory findings. The 2019 consensus update by Asian working group for sarcopenia was used to assess whether a MHD patient had sarcopenia. Finally, 140 male (58 with possible sarcopenia or sarcopenia) and 102 female (65 with possible sarcopenia or sarcopenia) patients' data were collected. Participants were divided into sarcopenia and control groups for each sex to develop binary classifiers. After statistical analysis and feature selection, stratified shuffle split and Synthetic Minority Oversampling Technique were conducted and voting classifiers were developed.

resultsAfter eliminating handgrip strength, 6-m walk, and skeletal muscle index, the best three features for sarcopenia identification of male patients are age, fasting blood glucose, and parathyroid hormone. Meanwhile, age, arm without vascular access, total bilirubin, and post-dialysis creatinine are the best four features for females. After abandoning models with overfitting or bad performance, voting classifiers achieved good sarcopenia classification performance for both sexes (For males: sensitivity: 77.50% ± 11.21%, specificity: 83.13% ± 9.70%, F1 score: 77.32% ± 5.36%, the area under the receiver operating characteristic curves (AUC): 87.40% ± 4.41%. For females: sensitivity: 76.15% ± 13.95%, specificity: 71.25% ± 15.86%, F1 score: 78.04% ± 8.85%, AUC: 77.69% ± 7.92%).

conclusionsTwo simple sex-specific sarcopenia identification tools for MHD patients were developed. They performed well on the case finding of sarcopenia, especially possible sarcopenia.

Indexed as

SarcopeniaFemaleHand StrengthHumansMaleMuscle, SkeletalRenal DialysisRetrospective StudiesIdentificationMachine LearningMaintenance HemodialysisSarcopenia

Identifiers

PMID36788486
PMCPMC9930261

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.