Evidence map›Paper›PMID 36788536›Full record

ArticleBMC medicine2023

Maternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study.

Jerod M Rasmussen, Jetro J Tuulari, Saara Nolvi, Paul M Thompson, Harri Merisaari, Maria Lavonius, Linnea Karlsson, Sonja Entringer, Pathik D Wadhwa, Hasse Karlsson and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Jerod M Rasmussen *Development, Health and Disease Research Program, University of California, Irvine, CA, 92697, USA. rasmussj@hs.uci.edu.ORCID 0000-0002-9400-7750
Jetro J Tuulari *FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Lemminkäisenkatu 2, 20520, Turku, Finland.
Saara NolviFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Lemminkäisenkatu 2, 20520, Turku, Finland.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Harri MerisaariFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Lemminkäisenkatu 2, 20520, Turku, Finland.
Maria LavoniusFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Lemminkäisenkatu 2, 20520, Turku, Finland.
Linnea KarlssonFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Lemminkäisenkatu 2, 20520, Turku, Finland.
Sonja EntringerDevelopment, Health and Disease Research Program, University of California, Irvine, CA, 92697, USA.
Pathik D WadhwaDevelopment, Health and Disease Research Program, University of California, Irvine, CA, 92697, USA.
Hasse KarlssonFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Lemminkäisenkatu 2, 20520, Turku, Finland.
Claudia BussDevelopment, Health and Disease Research Program, University of California, Irvine, CA, 92697, USA.
University of Turku · FIUniversity of California, Irvine · USUniversity of Southern California · US

Funding

Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUG3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI BARRETT, EMILY S, MILLER, RICHARD KERMIT · 2016 to 2024
$7.0M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
FETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAINR01MH091351 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, WADHWA, PATHIK D · 2011 to 2015
$3.3M
Fetal Programming of Human Newborn Energy Homeostasis Brain NetworksR00HD100593 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI RASMUSSEN, JEROD MICHAEL · 2023 to 2025
$744k
Human Newborn Energy Homeostasis Brain Networks And Infant AdiposityR21DK118578 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI THOMPSON, PAUL M, WADHWA, PATHIK D · 2019 to 2020
$351k
Fetal Programming of Human Newborn Energy Homeostasis Brain Networks And Infant AdiposityK99HD100593 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI RASMUSSEN, JEROD MICHAEL · 2019 to 2021
$272k
NICHD NIH HHS K99 HD100593NICHD NIH HHS R00 HD100593NICHD NIH HHS R01 HD060628NIDDK NIH HHS R21 DK118578NIH HHS UG3 OD023349NIMH NIH HHS R01 MH091351
6 · The paper itself

Abstract

backgroundAn extensive body of animal literature supports the premise that maternal obesity during pregnancy can alter the development of the fetal hypothalamus (HTH, a critical regulator of energy balance) with implications for offspring obesity risk (i.e., long-term energy imbalance). Yet, the relationship in humans between maternal overweight/obesity during pregnancy and fetal hypothalamic development remains largely unknown. Here, using an international (Finland and California, USA) multi-site diffusion tensor imaging (DTI) dataset, we test the hypothesis that maternal pre-pregnancy BMI is associated with newborn offspring HTH mean diffusivity (HTH MD, a replicable neural correlate of BMI in adults).

methodsHTH MD was independently quantified in two separate BMI-matched cohorts (up to class II obesity; BMI

resultsThe distribution of maternal pre-pregnancy BMI was comparable across sites but differed by ethnicity and socioeconomic status. A positive linear association between maternal pre-pregnancy BMI and newborn offspring HTH MD was observed at both sites ([Formula: see text]

conclusionsThese findings translate the preclinically established association between maternal obesity during pregnancy and offspring hypothalamic microstructure to the human context. In addition to further replication/generalization, future efforts to identify biological mediators of the association between maternal obesity and fetal HTH development are warranted to develop targeted strategies for the primary prevention of childhood obesity.

Indexed as

Pediatric ObesityPregnancy in ObesityAdultAnimalsBirth WeightBody Mass IndexChildCohort StudiesDiffusion Tensor ImagingFemaleHumansInfant, NewbornParturitionPregnancyProspective StudiesRisk FactorsFetal programmingHypothalamusInfantObesityPregnancy

Identifiers

PMID36788536
PMCPMC9930241
OpenAlexW4320725522

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.