Trial reportEndocrinology, diabetes & metabolism2023
Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes.
Trial report in Endocrinology, diabetes & metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Cognitive skills in children and adolescents with type 1 diabetes: a scoping review and meta-analysis.BMJ open diabetes research & care · 2026Pooled it
- Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes.Endocrinology, diabetes & metabolism · 2023Trial
- Tailoring interventions to close gaps in diabetes mellitus care.Nature reviews. Endocrinology · 2026Review
- An international consensus on screening and monitoring early-stage type 1 diabetes: A roadmap to European implementation.Diabetes, obesity & metabolism · 2026Review
- Protection through early knowledge: clinical onset of type 1 diabetes in children and adolescents with and without early T1D detection programmes.BMC pediatrics · 2026Article
- The Impact of Diabetes on Brain Health in Childhood.Biomedicines · 2026Review
- Clinical Aspects and Molecular Mechanisms of Cognitive Dysfunction in Children and Adolescents with Type 1 Diabetes.Children (Basel, Switzerland) · 2026Review
- Intervention to reduce barriers to type 1 diabetes self-management: Diabetes Journey study design and participant characteristics.Contemporary clinical trials · 2025Article
- Article
- Severe Diabetic Ketoacidosis in Children with Type 1 Diabetes: Ongoing Challenges in Care.Children (Basel, Switzerland) · 2025Review
- EDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents.BMJ open · 2025Article
- [Early Detection Of Type 1 Diabetes By Islet Autoantibody Screening: A Position Paper Of The Fr1daplex Project Leaders And Training Centres, Bvkj Bavaria And Paednetz (Registered) Bavaria].Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) · 2025Article
- Changes in the clinical picture of type 1 diabetes in children at diagnosis: past hopelessness in face of diabetic ketoacidosis vs. current hope for prevention and cure in the early stages of diabetes with developing treatment possibilities.Pediatric endocrinology, diabetes, and metabolism · 2025Article
- Asthma and Memory Function in Children.JAMA network open · 2024Observational
- A multi-ancestry genome-wide association study in type 1 diabetes.Human molecular genetics · 2024Article
- Use of teplizumab in children and adolescents at risk of type 1 diabetes: perspectives of parents and caregivers from an Italian Pediatric Diabetes Center.Acta diabetologica · 2024Article
- Early expression of neuroinflammation in an untreated fatal case of diabetic ketoacidosis.Archives of endocrinology and metabolism · 2024Article
- The effect of poor glycemic control on cognitive function in children and adolescents with type 1 diabetes mellitus: A single-center cross-sectional study (2019-2020).Saudi medical journal · 2023Article
- Emergency Department Presentations of Diabetic Ketoacidosis in a Large Cohort of Children.Pediatric diabetes · 2023Article
Corrections and comments
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Authors and funding
19 authors at 13 institutions in 1 country.
Funding
Abstract
introductionYoung children with type 1 diabetes (T1D) may be at particularly high risk of cognitive decline following diabetic ketoacidosis (DKA). However, studies of cognitive functioning in T1D typically examine school-age children. The goal of this study was to examine whether a single experience of DKA is associated with lower cognitive functioning in young children. We found that recently diagnosed 3- to 5-year-olds who experienced one DKA episode, regardless of its severity, exhibited lower IQ scores than those with no DKA exposure.
methodsWe prospectively enrolled 46 3- to 5-year-old children, who presented with DKA at the onset of T1D, in a randomized multi-site clinical trial evaluating intravenous fluid protocols for DKA treatment. DKA was moderate/severe in 22 children and mild in 24 children. Neurocognitive function was assessed once 2-6 months after the DKA episode. A comparison group of 27 children with T1D, but no DKA exposure, was also assessed. Patient groups were matched for age and T1D duration at the time of neurocognitive testing.
resultsChildren who experienced DKA, regardless of its severity, exhibited significantly lower IQ scores than children who did not experience DKA, F(2, 70) = 6.26, p = .003, partial η
conclusionsA single DKA episode is associated with lower IQ scores soon after exposure to DKA in young children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.