Evidence map›Paper›PMID 36789495›Full record

ArticleJournal of diabetes investigation2023

Factors associated with hemoglobin glycation index in adults with type 1 diabetes mellitus: The FGM-Japan study.

Naoki Sakane, Yushi Hirota, Akane Yamamoto, Junnosuke Miura, Hiroko Takaike, Sari Hoshina, Masao Toyoda, Nobumichi Saito, Kiminori Hosoda, Masaki Matsubara and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Naoki SakaneDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.ORCID https://orcid.org/0000-0002-2625-571X
Yushi HirotaDivision of Diabetes and Endocrinology, The Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan.ORCID https://orcid.org/0000-0002-3035-4155
Akane YamamotoDivision of Diabetes and Endocrinology, The Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan.
Junnosuke MiuraDivision of Diabetology and Metabolism, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-5115-1111
Hiroko TakaikeDivision of Diabetology and Metabolism, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-9531-2802
Sari HoshinaDivision of Diabetology and Metabolism, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Masao ToyodaDivision of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.ORCID https://orcid.org/0000-0003-4142-1218
Nobumichi SaitoDivision of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Kiminori HosodaDivision of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, Osaka, Japan.
Masaki MatsubaraDivision of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular Center, Osaka, Japan.
Atsuhito ToneDepartment of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, Japan.
Satoshi KawashimaKanda Naika Clinic, Osaka, Japan.
Hideaki SawakiSawaki Internal Medicine and Diabetes Clinic, Osaka, Japan.
Tomokazu MatsudaMatsuda Diabetes Clinic, Kobe, Japan.
Masayuki DomichiDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Akiko SuganumaDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Seiko SakaneDivision of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Takashi MurataDepartment of Clinical Nutrition, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.ORCID https://orcid.org/0000-0001-8634-9657
Kyoto Medical Center · JPTokyo Women's Medical University · JPDiabetes Australia · AUKobe University · JPNational Cerebral and Cardiovascular Center · JPTokai University · JPKaneka (Japan) · JPOkayama Saiseikai General Hospital · JP

Funding

Japan Agency for Medical Research and Development (AMED) 18ek0210104h0001Japan Agency for Medical Research and Development (AMED) 19ek0210104h0002Japan Agency for Medical Research and Development (AMED) 20ek0210104h0003
6 · The paper itself

Abstract

AIMS/

introductionThe discrepancy between HbA1c and glucose exposure may have significant clinical implications; however, the association between the hemoglobin glycation index (HGI) and clinical parameters in type 1 diabetes remains controversial. This study aimed to find the factors associated with HGI (laboratory HbA1c - predicted HbA1c derived from the continuous glucose monitoring [CGM]). MATERIALS AND

methodsWe conducted a cross-sectional study of adults with type 1 diabetes (n = 211, age 50.9 ± 15.2 years old, female sex = 59.2%, duration of CGM use = 2.1 ± 1.0 years). All subjects wore the CGM for 90 days before HbA1c measurement. Data derived from the FreeStyle Libre sensor were used to calculate the glucose management indicator (GMI) and glycemic variability (GV) parameters. HGI was defined as the difference between the GMI and the laboratory HbA1c levels. The participants were divided into three groups according to the HGI tertile (low, moderate, and high). Multivariate regression analyses were performed.

resultsThe female sex ratio, HbA1c, and % coefficient of variation (%CV) significantly increased over the HGI tertile, while eGFR and Hb decreased over the HGI tertile. In multivariate analysis, the factors associated with HGI were %CV and eGFR, after adjusting for HbA1c level and sex (R

conclusionsThis study demonstrated that HGI is associated with female sex, eGFR, and some glycemic variability indices, independently of HbA1c. Minimizing glycemic fluctuations might reduce HGI. This information provides diabetic health professionals and patients with personalized diabetes management for adults with type 1 diabetes.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2AdultAgedBlood GlucoseBlood Glucose Self-MonitoringCross-Sectional StudiesFemaleGlycated HemoglobinHemoglobinsHumansJapanMaillard ReactionMiddle AgedBlood GlucoseGlycated HemoglobinHemoglobinsContinuous glucose monitoringGlycated hemoglobin A1cGlycemic variability

Identifiers

PMID36789495
PMCPMC10034957
OpenAlexW4320857915

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.