Evidence map›Paper›PMID 36789686›Full record

ArticleActa biochimica et biophysica Sinica2022

ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells.

Ying Lv, Sijie Xiao, Shuhui Ouyang, Zhengliang Peng, Li Wu, Ziqing Tang, Weizheng Zhang, Renxian Cao, Jing Yang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ying LvThe First Affiliated Hospital, Department of Clinical Research, Hengyang Medical School, University of South China, Hengyang 421001, China.
Sijie XiaoThe First Affiliated Hospital, Department of Metabolism and Endocrinology, Hengyang Medical School, University of South China, Hengyang 421001, China.
Shuhui OuyangThe First Affiliated Hospital, Department of Clinical Research, Hengyang Medical School, University of South China, Hengyang 421001, China.
Zhengliang PengThe First Affiliated Hospital, Department of Emergency, Hengyang Medical School, University of South China, Hengyang 421001, China.
Li WuThe First Affiliated Hospital, Department of Metabolism and Endocrinology, Hengyang Medical School, University of South China, Hengyang 421001, China.
Ziqing TangThe First Affiliated Hospital, Department of Metabolism and Endocrinology, Hengyang Medical School, University of South China, Hengyang 421001, China.
Weizheng ZhangThe First Affiliated Hospital, Department of Metabolism and Endocrinology, Hengyang Medical School, University of South China, Hengyang 421001, China.
Renxian CaoThe First Affiliated Hospital, Department of Clinical Research, Hengyang Medical School, University of South China, Hengyang 421001, China.
Jing YangThe First Affiliated Hospital, Department of Clinical Research, Hengyang Medical School, University of South China, Hengyang 421001, China.
First Affiliated Hospital of University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipotoxicity has been shown to induce the loss of functional β-cell mass and lead to type 2 diabetes, but the mechanism remains unknown. In this study, we aim to explore the role of secretagogin (SCGN) in lipotoxicity-induced β-cell injury. Our results indicate that ox-LDL treatment leads to autophagic cell death, as evidenced by decreased cell viability, aggravated cell apoptosis, and the accumulation of the p62 protein in MIN6 cells. LysoTracker Red staining, TEM and mRFP-GFP-LC3 assays demonstrate that autophagic flux is blocked in ox-LDL-treated MIN6 cells. Intriguingly, SCGN is significantly decreased in MIN6 cells under lipotoxic conditions. Additionally, siRNA-guided

Indexed as

Autophagic Cell DeathDiabetes Mellitus, Type 2ApoptosisAutophagyHumansLipoproteins, LDLSecretagoginsLipoproteins, LDLoxidized low density lipoproteinSecretagoginsapoptosisautophagic fluxlipotoxicitysecretagoginβ-cells

Identifiers

PMID36789686
PMCPMC10157621
OpenAlexW4310681970

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.