ArticleeLife2023
Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.
Open access · goldAbstract read
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Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
16.0field-weighted citation impact, top 1% of its field
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Who cites it
38 citing papers in PubMed, 51 citations in OpenAlex.
- Aberrant PCM1 accumulation in Trisomy 21 mislocalizes E3 ligases, delaying primary ciliogenesis.bioRxiv : the preprint server for biology · 2026Article
- Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis.Brain : a journal of neurology · 2026Article
- Review
- Centrosome-Signaling Pathway Crosstalk: A Core Hub From Cellular Homeostasis to Disease.Cytoskeleton (Hoboken, N.J.) · 2026Review
- Bardet-Biedl syndrome 1 mutations differentially impact BBSome integrity and ciliary trafficking.Cell communication and signaling : CCS · 2026Article
- Proximity proteomics reveals a co-evolved LRRK2-regulatory network linked to centrosomes.EMBO reports · 2026Article
- The cell cycle variant in multiciliated cells incorporates 2 centriole biogenesis cycles.bioRxiv : the preprint server for biology · 2026Article
- Centriolar satellites regulatebioRxiv : the preprint server for biology · 2026Article
- PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate.Nature communications · 2025Article
- Inactivation of microtubule organizing center function of the centrosome is required for neuronal development and centriole elimination.bioRxiv : the preprint server for biology · 2025Article
- Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- SubCell: Proteome-aware vision foundation models for microscopy capture single-cell biology.bioRxiv : the preprint server for biology · 2025Article
- Molecular treatment options for patients carryingMolecular therapy. Nucleic acids · 2025Article
- The interplay between Wnt and mTOR signaling modulates ciliogenesis in human retinal epithelial cells.PLoS biology · 2025Article
- CCHCR1 links P-body proteins to the centrosome and is required for ciliogenesis through interacting with OFD1 and PCM1.Cellular & molecular biology letters · 2025Article
- A conserved role for centriolar satellites in translation of centrosomal and ciliary proteins.The Journal of cell biology · 2025Article
- The Unkempt RNA-binding protein reveals a local translation program in centriole overduplication.The Journal of cell biology · 2025Article
- Article
- Coordinated roles of the CEP164 homodimer and TTBK2 are required for recruitment of the IFT machinery to the mother centriole for ciliogenesis.Molecular biology of the cell · 2025Article
- Synchronized temporal-spatial analysis via microscopy and phosphoproteomics (STAMP) of quiescence.Science advances · 2025Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 5 countries.
Emma A Hall *MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-6944-6719
Dhivya Kumar *Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, United States.ORCID 0000-0002-3737-014X
Suzanna L ProsserLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.
Patricia L YeyatiMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Vicente Herranz-PérezCavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, Valencia, Spain.ORCID 0000-0002-1969-1214
Jose Manuel García-VerdugoCavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, Valencia, Spain.
Lorraine RoseMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Lisa McKieMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Daniel O DoddMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Peter A TennantMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Roly MegawMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-5605-4540
Laura C MurphyInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Marisa F FerreiraMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-8123-4612
Graeme GrimesMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Lucy WilliamsMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Tooba QuidwaiMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-5248-9010
Laurence PelletierLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.ORCID 0000-0003-1171-4618
Jeremy F ReiterDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, United States.ORCID 0000-0002-6512-320X
Pleasantine MillMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-5218-134X
Institute of Genetics and Cancer · GBUniversity of California, San Francisco · USEdinburgh Cancer Research · GBLunenfeld-Tanenbaum Research Institute · CAUniversitat de València · ESUniversitat Jaume I · ESUniversity of Toronto · CA
Funding
Hedgehog signaling at the cell's antenna: Smoothened and the primary ciliumR01AR054396 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy F Reiter · 2007 to 2026
$9.0MTransition zone control of ciliary signalingR01GM095941 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F · 2011 to 2018
$3.4MUnderstanding Ciliary Functions in Mammalian DevelopmentR01HD089918 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F, YODER, BRADLEY K. · 2017 to 2021
$3.0MTransition zone control of ciliary signalingR01DE029454 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F · 2019 to 2022
$2.3MMechanisms underlying centriole morphogenesisK99GM140175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KUMAR, DHIVYA · 2022 to 2023
$132kMarie Curie 702601Medical Research Council MC_UU_00007/14Medical Research Council MC_UU_12018/26Medical Research Council MR_UU_1201018/26NIAMS NIH HHS R01 AR054396NICHD NIH HHS R01 HD089918NIDCR NIH HHS R01 DE029454NIGMS NIH HHS K99 GM140175NIGMS NIH HHS R01 GM095941NIH HHS 5K99GM140175NIH HHS R01AR054396NIH HHS R01GM095941NIH HHS RO1HD089918
Abstract
Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by Pericentriolar material 1 (PCM1). To study the requirement for centriolar satellites, we generated mice lacking PCM1, a crucial component of satellites.
Indexed as
CentriolesCiliaAnimalsCell Cycle ProteinsCentrosomeCytoskeletal ProteinsFemaleHumansMiceCell Cycle ProteinsCytoskeletal ProteinsPcm1 protein, mousecentriolar satellitescentriolecentrosomeciliaciliary vesicleciliogenesiscondensatesdevelopmental biologyhumanmouse
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.