ArticleBrain and behavior2023
Posterior cingulate cortex targeted real-time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default-mode network in PTSD.
Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Meta-analytic connectivity perturbation analysis (MACPA): a new method for enhanced precision in fMRI connectivity analysis.Brain structure & function · 2024Pooled it
- Posterior cingulate cortex downregulation training using fMRI neurofeedback in adolescents with early life adversity exposure: a randomized, single-blind trial.Translational psychiatry · 2025Trial
- Cumulative trauma, neural circuits, and burnout: an integrative model of healthcare worker post-traumatic stress syndromes.European journal of psychotraumatology · 2026Review
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- From classic circuits to novel mechanisms: How lncRNA, neuroinflammation, and iPSC models address the translational crisis in PTSD research.Comprehensive psychoneuroendocrinology · 2026Review
- Augmenting evidence-based PTSD psychotherapy with neuroscientifically informed interventions: A mind-body-brain approach.Journal of military, veteran and family health · 2026Article
- Self-Processing Circuits Among Depressed Youth After Amygdala Neurofeedback Cued to the Self-Face.Journal of neuroscience research · 2025Article
- Neurobiological and Existential Profiles in Posttraumatic Stress Disorder: The Role of Serotonin, Cortisol, Noradrenaline, and IL-12 Across Chronicity and Age.International journal of molecular sciences · 2025Article
- The Psychopathological Domains of Attachment Trauma: A Proposal for a Clinical Conceptualization.Clinical neuropsychiatry · 2025Article
- Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Functional connectivity profiles of amygdala subregions in posttraumatic stress disorder.Translational psychiatry · 2025Article
- Study protocol for a multi-session randomized sham-controlled trial of PCC- and amygdala-targeted neurofeedback for the treatment of PTSD.BMC psychiatry · 2025Article
- It's all connected! Multivariate pattern analysis of inter-network connectivity distinguishes between reappraisal and passive viewing of emotional scenes.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Therapeutic emergence of dissociated traumatic memories during psilocybin treatment for anorexia nervosa.Journal of eating disorders · 2025Article
- Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.Nature. Mental health · 2025Article
- Exploring the impact of biological sex on intrinsic connectivity networks in PTSD: A data-driven approach.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- Neural correlates and plasticity of explicit emotion regulation following the experience of trauma.Frontiers in behavioral neuroscience · 2025Review
- A network analysis of eating disorder, PTSD, major depression, state-trait anxiety, and quality of life measures in eating disorder patients treated in residential care.European eating disorders review : the journal of the Eating Disorders Association · 2025Article
- Impaired interoception in Colombian victims of armed conflict with PTSD: a preliminary HEP study.Frontiers in psychology · 2025Article
- Genetic Vulnerability to Social Anxiety Disorder.Current topics in behavioral neurosciences · 2025Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundAlterations within large-scale brain networks-namely, the default mode (DMN) and salience networks (SN)-are present among individuals with posttraumatic stress disorder (PTSD). Previous real-time functional magnetic resonance imaging (fMRI) and electroencephalography neurofeedback studies suggest that regulating posterior cingulate cortex (PCC; the primary hub of the posterior DMN) activity may reduce PTSD symptoms and recalibrate altered network dynamics. However, PCC connectivity to the DMN and SN during PCC-targeted fMRI neurofeedback remains unexamined and may help to elucidate neurophysiological mechanisms through which these symptom improvements may occur.
methodsUsing a trauma/emotion provocation paradigm, we investigated psychophysiological interactions over a single session of neurofeedback among PTSD (n = 14) and healthy control (n = 15) participants. We compared PCC functional connectivity between regulate (in which participants downregulated PCC activity) and view (in which participants did not exert regulatory control) conditions across the whole-brain as well as in a priori specified regions-of-interest.
resultsDuring regulate as compared to view conditions, only the PTSD group showed significant PCC connectivity with anterior DMN (dmPFC, vmPFC) and SN (posterior insula) regions, whereas both groups displayed PCC connectivity with other posterior DMN areas (precuneus/cuneus). Additionally, as compared with controls, the PTSD group showed significantly greater PCC connectivity with the SN (amygdala) during regulate as compared to view conditions. Moreover, linear regression analyses revealed that during regulate as compared to view conditions, PCC connectivity to DMN and SN regions was positively correlated to psychiatric symptoms across all participants.
conclusionIn summary, observations of PCC connectivity to the DMN and SN provide emerging evidence of neural mechanisms underlying PCC-targeted fMRI neurofeedback among individuals with PTSD. This supports the use of PCC-targeted neurofeedback as a means by which to recalibrate PTSD-associated alterations in neural connectivity within the DMN and SN, which together, may help to facilitate improved emotion regulation abilities in PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.