Evidence map›Paper›PMID 36793283›Full record

ArticleFrontiers in endocrinology2023

Systematic analysis of the BET family in adrenocortical carcinoma: The expression, prognosis, gene regulation network, and regulation targets.

Yongli Situ, Quanyan Liang, Ziying Zeng, Jv Chen, Zheng Shao, Qinying Xu, Xiaoyong Lu, Yongshi Cui, Juying Zhang, Lingling Lu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Cancer biology & therapy · 2024
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yongli SituDepartment of Parasitology, Guangdong Medical University, Zhanjiang, Guangdong, China.
Quanyan LiangDepartment of Parasitology, Guangdong Medical University, Zhanjiang, Guangdong, China.
Ziying ZengDepartment of Parasitology, Guangdong Medical University, Zhanjiang, Guangdong, China.
Jv ChenDepartment of Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Zheng ShaoDepartment of Parasitology, Guangdong Medical University, Zhanjiang, Guangdong, China.
Qinying XuDepartment of Parasitology, Guangdong Medical University, Zhanjiang, Guangdong, China.
Xiaoyong LuDepartment of Parasitology, Guangdong Medical University, Zhanjiang, Guangdong, China.
Yongshi CuiDepartment of Parasitology, Guangdong Medical University, Zhanjiang, Guangdong, China.
Juying ZhangDepartment of Parasitology, Guangdong Medical University, Zhanjiang, Guangdong, China.
Lingling LuDepartment of Parasitology, Guangdong Medical University, Zhanjiang, Guangdong, China.
Li DengDepartment of Parasitology, Guangdong Medical University, Zhanjiang, Guangdong, China.
Guangdong Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bromodomain and extracellular terminal (BET) family (including BRD2, BRD3, and BRD4) is considered to be a major driver of cancer cell growth and a new target for cancer therapy. Currently, more than 30 targeted inhibitors have shown significant inhibitory effects against various tumors in preclinical and clinical trials. However, the expression levels, gene regulatory networks, prognostic value, and target prediction of Methods: We systematically analyzed the expression, prognosis, gene regulatory network, and regulatory targets of Results: The expression levels of Conclusions: The findings of this study provide a partial basis for the role of

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical CarcinomaMicroRNAsBromodomain Containing ProteinsCell Cycle ProteinsGene Regulatory NetworksHumansKruppel-Like Transcription FactorsNerve Tissue ProteinsNuclear ProteinsPrognosisProtein DomainsProtein Serine-Threonine KinasesRibonucleoprotein, U4-U6 Small NuclearTranscription FactorsBRD4 protein, humanBromodomain Containing ProteinsCDK5RAP2 protein, humanCell Cycle ProteinsKruppel-Like Transcription FactorsMicroRNAsNerve Tissue ProteinsNuclear ProteinsProtein Serine-Threonine KinasesPRPF4B protein, humanRibonucleoprotein, U4-U6 Small NuclearTranscription FactorsWIZ protein, humanadrenocortical carcinomaBRD2BRD3BRD4gene regulation networkPFI-1target prediction

Identifiers

PMID36793283
PMCPMC9922706
OpenAlexW4318590426

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.