Evidence map›Paper›PMID 36793929›Full record

ArticleInfectious microbes & diseases2022

Bicarbonate Effects on Antibacterial Immunity and Mucus Glycobiology in the Cystic Fibrosis Lung: A Review With Selected Experimental Observations.

Ruth Siew, Tzung-Lin Ou, Samira Dahesh, Kathryn Akong, Victor Nizet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious microbes & diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Complete genome sequence of pathogenicMicrobiology resource announcements · 2025
    Article
  4. Defects in anaplerotic metabolism sensitizeMicrobiology spectrum · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ruth SiewDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Tzung-Lin OuSchool of Medicine, China Medical University, Taichung, Taiwan.
Samira DaheshDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Kathryn AkongDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Victor NizetDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
University of California, San Diego · USChina Medical University · TW

Funding

UCSD Biomedical Scientist Career Development Program in GlycoscienceK12HL141956 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D, GODULA, KAMIL · 2018 to 2022
$5.3M
Surprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune SensitizationR01AI145310 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMARASWAMY, MONIKA, NIZET, VICTOR · 2020 to 2023
$1.9M
Developing Pediatric Clinical Pharmacologists for the Advancement of TherapeuticsT32HD087978 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, TREMOULET, ADRIANA H · 2016 to 2025
$1.5M
Glycan-Lectin Receptor Regulation of Macrophage Maturation and Lung InnateDefenses in the Fetus and Newborn InfantR01AI142864 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, PRINCE, LAWRENCE S · 2019 to 2021
$1.2M
NHLBI NIH HHS K12 HL141956NIAID NIH HHS R01 AI142864NIAID NIH HHS R01 AI145310NICHD NIH HHS T32 HD087978
6 · The paper itself

Abstract

The primary defect in cystic fibrosis (CF) is abnormal chloride and bicarbonate transport in the cystic fibrosis transmembrane conductance regulator (CFTR) epithelial ion channel. The apical surface of the respiratory tract is lined by an airway surface liquid layer (ASL) composed of mucin comprising mainly MUC5A and MUC5B glycoproteins. ASL homeostasis depends on sodium bicarbonate secretion into the airways and secretion deficits alter mucus properties leading to airway obstruction, inflammation, and infections. Downstream effects of abnormal ion transport in the lungs include altered intrinsic immune defenses. We observed that neutrophils killed

Indexed as

bacterial infectionbicarbonatecathelicidincystic fibrosismucusneutrophilneutrophil extracellular trapspneumonia

Identifiers

PMID36793929
PMCPMC9928163
OpenAlexW4290948881

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.