ArticleJournal of endocrinological investigation2023
Impaired sensitivity to thyroid hormone correlates to osteoporosis and fractures in euthyroid individuals.
Article in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Association between thyroid hormone sensitivity indices and renal function in community-dwelling euthyroid older adults: a cross-sectional study.Scientific reports · 2026Article
- Association of impaired sensitivity to thyroid hormone with low bone mineral density and bone mineral content.Frontiers in endocrinology · 2026Review
- Thyroid hormones and thyroid hormone sensitivity indices correlate with volumetric bone mineral density and vertebral fracture risk among the osteoporotic population in northern China.Frontiers in endocrinology · 2026Article
- Brain-bone axis dysregulation: Biological code underlying the bidirectional association between depression and musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- Impaired sensitivity to thyroid hormones is associated with atrial fibrillation in the euthyroid population.Frontiers in cardiovascular medicine · 2026Article
- Impaired sensitivity to thyroid hormones is associated with frailty in older patients with cardiometabolic disease.BMC geriatrics · 2025Article
- Association between thyroid function and thyroid homeostasis parameters and the prevalence and all-cause and cardiovascular mortality of chronic kidney disease: a population-based study.BMC public health · 2025Article
- A high FT3 level might protect bone mineral density among euthyroid type 2 diabetes mellitus patients.Endocrine connections · 2025Article
- Progress in multiaxial coupling mechanisms of osteoporosis: insights from systems medicine on immune-inflammatory interactions, hormonal regulation, and metabolic imbalance.Frontiers in endocrinology · 2025Review
- Pituitary-Thyroid Hormones and Related Indices in Euthyroid Type 2 Diabetes: Association With Thyroid Nodules.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association between impaired sensitivity to thyroid hormones and sedentary behavior: a cross-sectional study.Frontiers in medicine · 2025Article
- Establishment and Validation of a Predictive Nomogram Model for Osteoporosis in Postmenopausal Women with Type 2 Diabetes Mellitus: A Retrospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association between sensitivity to thyroid hormones and trabecular bone score in euthyroid individuals: a population-based cross-sectional study.BMC musculoskeletal disorders · 2024Article
- Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis.Scientific reports · 2024Article
- Association of sensitivity to thyroid hormones with all-cause mortality in euthyroid US adults: A nationwide cohort study.European thyroid journal · 2024Article
- A Case of Thyroid Hormone Resistance Syndrome with a Novel Mutation (c.947G>a) in theInternational medical case reports journal · 2024Article
- Higher Peripheral Thyroid Sensitivity Is Linked to a Lower Risk of Heart Failure After Acute Myocardial Infarction.The Journal of clinical endocrinology and metabolism · 2023Article
- Thyroid function and thyroid homeostasis parameters are associated with increased urinary albumin excretion in euthyroid individuals over 60 years old from NHANES.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is growing evidence that thyroid function affects bone metabolism and even fractures risk. However, little is known about the relationship between thyroid sensitivity and osteoporosis and fractures. Therefore, we explored the relationship between thyroid sensitivity-related indices and bone mineral density (BMD) and fractures in euthyroid US adults.
methodsIn this cross-sectional study, 20,686 subjects from National Health and Nutrition Examination Survey (NHANES) data were extracted and analyzed during 2007 to 2010. A total of 3403 men and postmenopausal women aged 50 years or older with available data on diagnosis of osteoporosis and/or fragility fractures, bone mineral density (BMD) and thyroid function, were eligible. TSH index (TSHI), thyrotrophin T4/T3 resistance index (TT4RI/TT3RI), Thyroid feedback quantile-based index (TFQI), Parametric TFQI (PTFQI), free triiodothyronine to free thyroxine ratio (FT3/FT4), the secretory capacity of the thyroid gland (SPINA-GT) and the sum activity of peripheral deiodinases (SPINA-GD) were calculated.
resultsFT3/FT4, SPINA-GD, FT4, TSHI, TT4RI, TFQI and PTFQI
conclusionsIn elderly euthyroid individuals, impaired sensitivity to thyroid hormones correlates to osteoporosis and fractures, independent of other conventional risk factors.
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