ArticleeLife2023
Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of
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Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
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Who cites it
58 citing papers in PubMed, 67 citations in OpenAlex.
- The impact of P-element-induced hybrid dysgenesis on the male germline in Drosophila simulans.Genetics · 2026Article
- Protocol for high-sensitivity detection of microRNAs in adult Drosophila tissues using hybridization chain reaction.STAR protocols · 2026Article
- The Lomb-Scargle periodogram-based differentially expressed gene detection along pseudotime.Nucleic acids research · 2026Article
- Somatic cells compartmentalise their carbohydrate metabolism to sustain germ cell survival.The EMBO journal · 2026Article
- Comparative single-nucleus transcriptomics reveals asymmetric evolution of the Drosophila male and female germlines.PLoS biology · 2026Article
- Differentiating spermatogonia trigger somatic support cells to form septate junctions required for germ cell survival.bioRxiv : the preprint server for biology · 2026Article
- Somatic cells non-autonomously control germline incomplete cytokinesis through FGF signaling.bioRxiv : the preprint server for biology · 2026Article
- Article
- Peroxisomal DBP deficiency causes male infertility through disruption of lipid homeostasis in Drosophila.Cellular and molecular life sciences : CMLS · 2026Article
- Defective transcription of AAGAG satellite DNA causes sex-ratio meiotic drive in Drosophila.Nature communications · 2026Article
- Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Defective transcription of AAGAG satellite DNA causes sex-ratio meiotic drive inbioRxiv : the preprint server for biology · 2026Article
- Stem cell competition.Current topics in developmental biology · 2026Review
- A catalog of mRNAs transferred from males to females during mating in Drosophila arizonae and D. mojavensis.PloS one · 2026Article
- Ionotropic glutamate receptor expression and function in themicroPublication biology · 2026Article
- The Tbx1 ortholog org-1 is required to establish testis stem cell niche identity in Drosophila.Development (Cambridge, England) · 2026Article
- Article
- Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program.PLoS biology · 2025Article
- Tissue-specific CLOCK isoforms modulate circadian feedback loops to govern reproductive fitness in Drosophila.Cellular and molecular life sciences : CMLS · 2025Article
- Cell type- and chromosome-specific chromatin landscapes and DNA replication programs ofbioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 10 institutions in 4 countries.
Amelie A Raz *Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, United States.ORCID 0000-0002-4651-0626
Gabriela S Vida *Department of Cell and Developmental Biology, The Perelman School of Medicine and The Penn Institute for Regenerative Medicine, Philadelphia, United States.
Sarah R Stern *Department of Developmental Biology, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-6518-7289
Sharvani Mahadevaraju *National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, United States.
Jaclyn M Fingerhut *Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, United States.ORCID 0000-0002-2347-0799
Jennifer M Viveiros *Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Soumitra Pal *National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, United States.ORCID 0000-0003-4840-3944
Jasmine R Grey *Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0001-6095-4461
Mara R Grace *Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Cameron W BerryDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, United States.
Hongjie LiHuffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Jasper JanssensJVIB Center for Brain & Disease Research, and the Department of Human Genetics, KU Leuven, Leuven, Belgium.
Wouter SaelensData Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, and Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.
Zhantao ShaoDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.
Chun HuDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.
Yukiko M YamashitaWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, United States.
Teresa PrzytyckaNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, United States.
Brian OliverNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, United States.
Julie A BrillCell Biology Program, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0002-5925-9901
Henry KrauseDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.
Erika L MatunisDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Helen White-CooperSchool of Biosciences, Cardiff University, Cardiff, United Kingdom.
Stephen DiNardoDepartment of Cell and Developmental Biology, The Perelman School of Medicine and The Penn Institute for Regenerative Medicine, Philadelphia, United States.ORCID 0000-0003-4131-5511
Margaret T FullerDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-3804-4987
Johns Hopkins University · USNational Institutes of Health · USUniversity of Toronto · CAHoward Hughes Medical Institute · USStanford University · USCalifornia Institute for Regenerative Medicine · USBaylor College of Medicine · USCardiff University · GBGhent University · BEVIB-KU Leuven Center for Brain & Disease Research · BE
Funding
Combinatorial and graph theoretical approach to systems biology and mol. evo.ZIALM200887 · NLM · NATIONAL LIBRARY OF MEDICINE · PI PRZYTYCKA, TERESA · 2009 to 2025
$24.4MDrosophila Functional GenomicsZIADK015600 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI OLIVER, BRIAN · 2009 to 2025
$23.9MGENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3MRegulation of proliferation and differentiation in the male germ line adult stem cell lineageR35GM136433 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER · 2020 to 2026
$5.9MPostgraduate Training Program in Epithelial BiologyT32AR007422 · NIAMS · STANFORD UNIVERSITY · PI PAUL KHAVARI · 1986 to 2026
$5.0MCellular plasticity in the Drosophila spermatogonial stem cell nicheR01HD052937 · NICHD · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, ERIKA L · 2007 to 2020
$3.8MRegulation of cellular plasticity and regeneration in Drosophila spermatogenesisR35GM136665 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Erika L Matunis · 2020 to 2026
$3.0MGenetics and Developmental Biology Training ProgramT32GM141828 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER, Gavin J Sherlock · 2022 to 2026
$2.6MControl of Stem Cell Dynamics by a Niche at Steady-State and During AgingR35GM136270 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DINARDO, STEPHEN FRANCIS · 2020 to 2024
$2.1MCharacterizing age-related decline of neural circuits by single-cell profilingR00AG062746 · NIA · BAYLOR COLLEGE OF MEDICINE · PI LI, HONGJIE · 2021 to 2023
$996kReprogramming towards a germline stem cell fateF32GM143850 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI RAZ, AMELIE · 2021 to 2023
$205kBiotechnology and Biological Sciences Research Council BB/P001564/1Howard Hughes Medical InstituteNIAMS NIH HHS T32 AR007422NIA NIH HHS R00 AG062746NICHD NIH HHS F31 HD108918NICHD NIH HHS R01 HD052937NIGMS NIH HHS F32 GM143850NIGMS NIH HHS R35 GM136270NIGMS NIH HHS R35 GM136433NIGMS NIH HHS R35 GM136665NIGMS NIH HHS T32 GM007790NIGMS NIH HHS T32 GM008216
Abstract
Proper differentiation of sperm from germline stem cells, essential for production of the next generation, requires dramatic changes in gene expression that drive remodeling of almost all cellular components, from chromatin to organelles to cell shape itself. Here, we provide a single nucleus and single cell RNA-seq resource covering all of spermatogenesis in
Indexed as
Adult Stem CellsTestisAnimalsDrosophilaMaleRNA-SeqSemenchromosomesdevelopmental biologyD. melanogastergene expressionlineagescRNA-seqsnRNA-seqspermatogenesisstem cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.