Evidence map›Paper›PMID 36796621›Full record

ArticleNeuroscience letters2023

Synaptotagmin-7 facilitates acetylcholine release in splanchnic nerve-chromaffin cell synapses during nerve activity.

René N Caballero-Florán, Mounir Bendahmane, Julie P Gupta, Xiaohuan Chen, Xiaojun Wu, Alina Morales, Arun Anantharam, Paul M Jenkins

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

René N Caballero-FloránDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States.
Mounir BendahmaneDepartment of Neuroscience, University of Toledo, Toledo, OH 43614, United States.
Julie P GuptaDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States.
Xiaohuan ChenDepartment of Neuroscience, University of Toledo, Toledo, OH 43614, United States.
Xiaojun WuDepartment of Neuroscience, University of Toledo, Toledo, OH 43614, United States.
Alina MoralesDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Department of Neuroscience, University of Toledo, Toledo, OH 43614, United States.
Arun AnantharamDepartment of Neuroscience, University of Toledo, Toledo, OH 43614, United States. Electronic address: arun.anantharam@utoledo.edu.
Paul M JenkinsDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48109, United States. Electronic address: pjenkins@umich.edu.
University of Toledo · USUniversity of Michigan · USUniversity of Toledo Medical Center · US

Funding

INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
Interdepartmental Training in Pharmacological SciencesT32GM140223 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lori L. Isom · 2021 to 2026
$3.8M
Pre- and postsynaptic pathways underlying the stress response in the adrenal medullaR01NS122534 · NINDS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI ANANTHARAM, ARUN · 2021 to 2025
$1.8M
NIGMS NIH HHS T32 GM007767NIGMS NIH HHS T32 GM140223NINDS NIH HHS R01 NS122534
6 · The paper itself

Abstract

Disturbances that threaten homeostasis elicit activation of the sympathetic nervous system (SNS) and the adrenal medulla. The effectors discharge as a unit to drive global and immediate changes in whole-body physiology. Descending sympathetic information is conveyed to the adrenal medulla via preganglionic splanchnic fibers. These fibers pass into the gland and synapse onto chromaffin cells, which synthesize, store, and secrete catecholamines and vasoactive peptides. While the importance of the sympatho-adrenal branch of the autonomic nervous system has been appreciated for many decades, the mechanisms underlying transmission between presynaptic splanchnic neurons and postsynaptic chromaffin cells have remained obscure. In contrast to chromaffin cells, which have enjoyed sustained attention as a model system for exocytosis, even the Ca

Indexed as

Adrenal MedullaChromaffin CellsAcetylcholineSplanchnic NervesSynapsesSynaptotagminsAcetylcholineSynaptotagminsAdrenal medullaPreganglionic synapsesSynaptotagminSynaptotagmin-7

Identifiers

PMID36796621
PMCPMC10145958
OpenAlexW4320717810

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.