ArticleNature communications2023
Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 45 citations in OpenAlex.
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- UltraFast Layer-Resolved Encoding (uFLARE) functional MRI deciphers bidirectional signaling from spontaneous activity.Nature communications · 2026Article
- Behavioral and brain-wide neural signatures of sundowning in Alzheimer's disease.Research square · 2026Article
- Biophysical mechanisms of default mode network function and dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Altered EEG-derived functional brain states in Parkinson's disease with mild cognitive impairment.Brain communications · 2026Article
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
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- Social pain is associated with altered developmental trajectories of connectivity among the triple network model of psychopathology.Social cognitive and affective neuroscience · 2025Article
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
- Impact of Anesthesia on Brain Functional Networks in Moyamoya Disease and Spinal Lesions.CNS neuroscience & therapeutics · 2025Article
- Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson's disease.Nature communications · 2025Article
- Deep linear matrix approximate reconstruction with integrated BOLD signal denoising reveals reproducible hierarchical brain connectivity networks from multiband multi-echo fMRI.Frontiers in neuroscience · 2025Article
- Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Two separate neural pathways, lateral and medial, for sensory decisions in mammals: switching of attention between the outer and inner cognitive worlds.Frontiers in neuroscience · 2025Article
- NIMH perspectives on future directions in neuroimaging for mental health.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- BrainTACO: an explorable multi-scale multi-modal brain transcriptomic and connectivity data resource.Communications biology · 2024Article
- Epilepsy alters brain networks in patients with insular glioma.CNS neuroscience & therapeutics · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The salience network (SN) and default mode network (DMN) play a crucial role in cognitive function. The SN, anchored in the anterior insular cortex (AI), has been hypothesized to modulate DMN activity during stimulus-driven cognition. However, the causal neural mechanisms underlying changes in DMN activity and its functional connectivity with the SN are poorly understood. Here we combine feedforward optogenetic stimulation with fMRI and computational modeling to dissect the causal role of AI neurons in dynamic functional interactions between SN and DMN nodes in the male rat brain. Optogenetic stimulation of Chronos-expressing AI neurons suppressed DMN activity, and decreased AI-DMN and intra-DMN functional connectivity. Our findings demonstrate that feedforward optogenetic stimulation of AI neurons induces dynamic suppression and decoupling of the DMN and elucidates previously unknown features of rodent brain network organization. Our study advances foundational knowledge of causal mechanisms underlying dynamic cross-network interactions and brain network switching.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.