Evidence map›Paper›PMID 36797613›Full record

SynthesisCurrent neuropharmacology2023

Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint.

Shikha Kushwah, Neha Shree Maurya, Sandeep Kushwaha, Luciana Scotti, Aakash Chawade, Ashutosh Mani

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Shikha KushwahDepartment of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, 211004, India.
Neha Shree MauryaDepartment of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, 211004, India.
Sandeep KushwahaNational Institute of Animal Biotechnology, Hyderabad, India.
Luciana ScottiFederal University of Paraiba, Cidade Universittária, Joao Pessoa, BR 58102100, Brazil.
Aakash ChawadeDepartment of Plant Breeding, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Ashutosh ManiDepartment of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, 211004, India.
Motilal Nehru National Institute of Technology · INNational Institute of Animal Biotechnology · INSwedish University of Agricultural Sciences · SEUniversidade Federal da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's is a chronic neurodegenerative disease where amyloid-beta (Aβ) plaques and neurofibrillary tangles are formed inside the brain. It is also characterized by progressive memory loss, depression, neuroinflammation, and derangement of other neurotransmitters. Due to its complex etiopathology, current drugs have failed to completely cure the disease. Natural compounds have been investigated as an alternative therapy for their ability to treat Alzheimer's disease (AD). Traditional herbs and formulations which are used in the Indian ayurvedic system are rich sources of antioxidant, anti-amyloidogenic, neuroprotective, and anti-inflammatory compounds. They promote quality of life by improving cognitive memory and rejuvenating brain functioning through neurogenesis. A rich knowledge base of traditional herbal plants (Turmeric, Gingko, Ashwagandha, Shankhpushpi, Giloy, Gotu kola, Garlic, Tulsi, Ginger, and Cinnamon) combined with modern science could suggest new functional leads for Alzheimer's drug discovery. In this article Ayurveda, the ancient Indian herbal medicine system based on multiple clinical and experimental, evidence have been reviewed for treating AD and improving brain functioning. This article presents a modern perspective on the herbs available in the ancient Indian medicine system as well as their possible mechanisms of action for AD treatment. The main objective of this research is to provide a systematic review of herbal drugs that are easily accessible and effective for the treatment of AD.

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesHumansOcimum sanctumPhytotherapyPlant ExtractsQuality of Lifeholy basil leaf extractPlant ExtractsAlzheimer'sAβ plaquescognitive memorymedicinal herbsneurodegenerativeneurofibrillary tangles

Identifiers

PMID36797613
PMCPMC10227917
OpenAlexW4321169270

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.