Evidence map›Paper›PMID 36798380›Full record

ArticlebioRxiv : the preprint server for biology2023

Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryo-electron microscopy.

Maxwell B Watkins, Haoyue Wang, Audrey Burnim, Nozomi Ando

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Maxwell B WatkinsDepartment of Chemistry, Princeton University, Princeton, NJ, 08544, USA.
Haoyue WangField of Biophysics, Cornell University, Ithaca, NY 14853, USA.
Audrey BurnimDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Nozomi AndoDepartment of Chemistry, Princeton University, Princeton, NJ, 08544, USA.
Cornell University · USPrinceton University · US

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Protein Allostery and Catalysis Beyond Bragg DiffractionR35GM124847 · NIGMS · PRINCETON UNIVERSITY · PI Nozomi Ando · 2017 to 2026
$4.1M
Structural Characterizations of Transient and Heterogeneous Protein ComplexesR00GM100008 · NIGMS · PRINCETON UNIVERSITY · PI ANDO, NOZOMI · 2014 to 2016
$747k
Lab Source for Small/Wide Angle X-ray Scattering ExperimentsS10OD028617 · OD · CORNELL UNIVERSITY · PI POLLACK, LOIS · 2020 to 2020
$549k
Structural Characterizations of Transient and Heterogeneous Protein ComplexesK99GM100008 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANDO, NOZOMI · 2012 to 2013
$176k
NIGMS NIH HHS K99 GM100008NIGMS NIH HHS R00 GM100008NIGMS NIH HHS R35 GM124847NIGMS NIH HHS U24 GM129539NIH HHS S10 OD028617
6 · The paper itself

Abstract

Cobalamin-dependent methionine synthase (MetH) catalyzes the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate (CH

Identifiers

PMID36798380
PMCPMC9934640
OpenAlexW4320169344

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.