Evidence mapPaperPMID 36798477Full record

ArticleACS pharmacology & translational science2023

Protective Effects of Rifampicin and Its Analog Rifampicin Quinone in a Mouse Model of Obesity-Induced Type 2 Diabetes.

Amit Garg, Maroof Alam, Shakuntala Bai, Monica Dandawate, Neeta Kumari, Sonu Gupta, Usha Agrawal, Perumal Nagarajan, Dumbala Srinivasa Reddy, Mahesh J Kulkarni and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Amit GargMolecular Aging Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.ORCID https://orcid.org/0000-0002-6774-3648
Maroof AlamMolecular Aging Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.ORCID https://orcid.org/0000-0002-5085-8094
Shakuntala BaiBiochemical Sciences Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.ORCID https://orcid.org/0000-0002-0943-2809
Monica DandawateCSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.ORCID https://orcid.org/0000-0003-0507-4124
Neeta KumariOrganic Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.ORCID https://orcid.org/0000-0003-1463-4437
Sonu GuptaMolecular Aging Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.ORCID https://orcid.org/0000-0002-4840-5678
Usha AgrawalICMR-National Institute of Pathology, Sriramachari Bhawan, Safdarjung Hospital Campus, New Delhi 110029, India.ORCID https://orcid.org/0000-0001-7539-4102
Perumal NagarajanMolecular Aging Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.ORCID https://orcid.org/0000-0003-4557-4633
Dumbala Srinivasa ReddyCSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.ORCID https://orcid.org/0000-0003-3270-315X
Mahesh J KulkarniBiochemical Sciences Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.ORCID https://orcid.org/0000-0003-3932-9092
Arnab MukhopadhyayMolecular Aging Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.ORCID https://orcid.org/0000-0002-5266-7849
National Chemical Laboratory · INNational Institute of Immunology · INSafdarjang Hospital · IN

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · UNIVERSITY OF MINNESOTA · 2025 to 2025
$455k
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Advanced glycation end-products (AGEs) form when glucose reacts non-enzymatically with proteins, leading to abnormal protein function, oxidative stress, and inflammation. AGEs are associated with aging and age-related diseases; their formation is aggravated during diabetes. Therefore, drugs preventing AGE formation can potentially treat diabetic complications, positively affecting health. Earlier, we demonstrated that rifampicin and its analogs have potent anti-glycating activities and increase the life span of

Identifiers

PMID36798477
PMCPMC9926524
OpenAlexW4315703405

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.