Evidence map›Paper›PMID 36801180›Full record

ArticleUltrasound in medicine & biology2023

Lung Ultrasound Protocol and Quality Control of Image Interpretation Using an Adjudication Panel in the Household Air Pollution Intervention Network (HAPIN) Trial.

Suzanne M Simkovich, Shakir Hossen, Eric D McCollum, Ashley K Toenjes, John P McCracken, Lisa M Thompson, Adly Castañaza, Anaite Diaz, Ghislaine Rosa, Miles A Kirby and 16 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02944682 (Household Air Pollution and Health), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02944682 nacompletednot on this map

Household Air Pollution and Health: A Multi-country LPG Intervention Trial

TypeinterventionalSponsorEmory UniversityRan2017 to 2025Enrolled3,640ConditionsInfant, Low Birth WeightArmsLiquefied petroleum gas (LPG) cookstove
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Suzanne M SimkovichDivision of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Division of Healthcare Delivery, MedStar Health Research Institute, Hyattsville, MD, USA; Division of Pulmonary and Critical Care Medicine, Georgetown University School of Medicine, Washington, DC, USA.
Shakir HossenDivision of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Eric D McCollumEudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Global Program on Pediatric Respiratory Sciences, Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Ashley K ToenjesCardiovascular Division, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
John P McCrackenGlobal Health Institute, Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.
Lisa M ThompsonNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
Adly CastañazaCenter for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
Anaite DiazCenter for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
Ghislaine RosaDepartment of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.
Miles A KirbyDepartment of Global Health and Population, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Alexie MukeshimanaEagle Research Center, Kigali, Rwanda.
Rachel MyersCardiovascular Division, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Patricia M LenzenCardiovascular Division, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Rachel CraikNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
Shirin JabbarzadehDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Lisa ElonDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Sarada S GargDepartment of Environmental Health Engineering, ICMR Center for Advanced Research on Air Quality, Climate and Health, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, India.
Kalpana BalakrishnanDepartment of Environmental Health Engineering, ICMR Center for Advanced Research on Air Quality, Climate and Health, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, India.
Gurusamy ThangavelDepartment of Environmental Health Engineering, ICMR Center for Advanced Research on Air Quality, Climate and Health, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, India.
Jennifer L PeelDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Thomas F ClasenDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Victor G Dávila-RománCardiovascular Division, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Aris T PapageorghiouNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
Lisa de las FuentesCardiovascular Division, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
William CheckleyDivision of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address: wcheckl1@jhmi.edu.
HAPIN Investigators

Funding

Household Air Pollution and Health: A Multi-Country LPG Intervention TrialUM1HL134590 · NHLBI · EMORY UNIVERSITY · PI CHECKLEY, WILLIAM, CLASEN, THOMAS F · 2016 to 2021
$31.1M
MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007534 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Nadia N Hansel, Larissa A. Shimoda · 1985 to 2026
$28.3M
Washington University K12 Program in T4 Implementation ResearchK12HL137942 · NHLBI · WASHINGTON UNIVERSITY · PI DAVILA-ROMAN, VICTOR G. · 2017 to 2021
$3.1M
Cost Effectiveness Analysis of an LPG Stove and Fuel Distribution Intervention.F32HL143909 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIMKOVICH, SUZANNE MARIE · 2018 to 2019
$140k
NHLBI NIH HHS F32 HL143909NHLBI NIH HHS K12 HL137942NHLBI NIH HHS T32 HL007534NHLBI NIH HHS UM1 HL134590
6 · The paper itself

Abstract

objectiveLung ultrasound (LUS) is an alternative to chest radiography to confirm a diagnosis of pneumonia. For research and disease surveillance, methods to use LUS to diagnose pneumonia are needed.

methodsIn the Household Air Pollution Intervention Network (HAPIN) trial, LUS was used to confirm a clinical diagnosis of severe pneumonia in infants. We developed a standardized definition of pneumonia, protocols for recruitment and training of sonographers, along with LUS image acquisition and interpretation. We use a blinded panel approach to interpretation with LUS cine-loops randomized to non-scanning sonographers with expert review. DISCUSSION: We obtained 357 lung ultrasound scans: 159, 8 and 190 scans were collected in Guatemala, Peru and Rwanda, respectively. The diagnosis of primary endpoint pneumonia (PEP) required an expert tie breaker in 181 scans (39%). PEP was diagnosed in 141 scans (40%), not diagnosed in 213 (60%), with 3 scans (<1%) deemed uninterpretable. Agreement among the two blinded sonographers and the expert reader in Guatemala, Peru and Rwanda was 65%, 62% and 67%, with a prevalence-and-bias-corrected kappa of 0.30, 0.24 and 0.33, respectively.

conclusionUse of standardized imaging protocols, training and an adjudication panel resulted in high confidence for the diagnosis of pneumonia using LUS.

Indexed as

Air PollutionPneumoniaHumansInfantLungQuality ControlRandomized Controlled Trials as TopicThoraxUltrasonographyDeveloping countriesImagingInfantPneumoniaResearch protocolRespiratory tract infectionsUltrasound

Identifiers

PMID36801180
PMCPMC10631486

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.