ArticleeLife2023
Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- STIM-Orai signaling in neurons: integrating calcium dynamics and synaptic plasticity.Cell communication and signaling : CCS · 2026Review
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Notch1 regulates Orai1 and Orai3 expression in breast cancer cells.Scientific reports · 2025Article
- A Large-Scale Single-Cell Atlas Reveals the Peripheral Immune Panorama of Bacterial Pneumonia.American journal of respiratory and critical care medicine · 2025Article
- Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway.Science signaling · 2025Article
- Orai channel pharmacological manipulation reduces metabolic flexibility in cardiac fibroblasts.American journal of physiology. Cell physiology · 2025Article
- Store-Operated Calcium Channels in the Nervous System.Annual review of physiology · 2025Review
- Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Article
- Orai1α and Orai1β support calcium entry and mammosphere formation in breast cancer stem cells.Scientific reports · 2023Article
- A multiple-oscillator mechanism underlies antigen-induced CaThe Journal of biological chemistry · 2023Article
- Opening Orai's to see B-yond current paradigms.Cell calcium · 2023Article
- Too much of a good thing: The case of SOCE in cellular apoptosis.Cell calcium · 2023Review
- Store-Operated CaContact (Thousand Oaks (Ventura County, Calif.))Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 1 country.
Scott M EmrichDepartment of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, United States.ORCID 0000-0002-4804-7436
Ryan E YoastDepartment of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, United States.
Xuexin ZhangDepartment of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, United States.
Adam J FikeDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, United States.
Yin-Hu WangDepartment of Pathology, New York University School of Medicine, New York, United States.
Kristen N BrickerDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, United States.ORCID 0000-0001-8963-9780
Anthony Y TaoDepartment of Pathology, New York University School of Medicine, New York, United States.
Ping XinDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Vonn WalterDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, United States.ORCID 0000-0001-6114-6714
Martin T JohnsonDepartment of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, United States.
Trayambak PathakDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Adam C StraubDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Stefan FeskeDepartment of Pathology, New York University School of Medicine, New York, United States.
Ziaur S M RahmanDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, United States.ORCID 0000-0001-8431-9681
Mohamed TrebakDepartment of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, United States.ORCID 0000-0001-6759-864X
Pennsylvania State University · USUniversity of Pittsburgh · USUniversity School · US
Funding
CRAC Channel Deficiency in Immunity to InfectionR01AI097302 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2012 to 2022
$5.6MCa2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4MBasic and Translational Studies in Redox Regulation of Cardiovascular Physiology and DiseaseR35HL161177 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Adam Carl Straub · 2022 to 2026
$4.7MIRF7-mediated development of autoreactive B cells and SLER01AI162971 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI RAHMAN, ZIAUR · 2021 to 2025
$2.7MRegulation of Follicular T cell Responses in the Lung by Ion ChannelsR01AI130143 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2017 to 2021
$2.4MStore-operated Orai3 calcium channels in metabolism and obesityK99HL163403 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PATHAK, TRAYAMBAK · 2022 to 2023
$209kThe role of ion channels and transporters in B cell functionF30AI164803 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TAO, ANTHONY · 2022 to 2024
$158kNHLBI NIH HHS K99 HL163403NHLBI NIH HHS R35 HL150778NHLBI NIH HHS R35-HL150778NHLBI NIH HHS R35 HL161177NIAID NIH HHS F30 AI164803NIAID NIH HHS F30-AI164803-01NIAID NIH HHS R01 AI097302NIAID NIH HHS R01-AI097302 and R01-AI130143NIAID NIH HHS R01 AI130143NIAID NIH HHS R01 AI162971NIAID NIH HHS R01-AI162971
Abstract
The essential role of store-operated Ca
Indexed as
B-LymphocytesCalcium ChannelsORAI1 ProteinAnimalsCalciumCalcium SignalingMiceStromal Interaction Molecule 1CalciumCalcium ChannelsORAI1 ProteinOrai1 protein, mouseOrai3 protein, mouseStromal Interaction Molecule 1B cellsbiochemistrycell biologychemical biologyCRAC channelsmetabolismmouseOrai1Orai3SOCE
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.