Evidence map›Paper›PMID 36804200›Full record

ArticleJournal of ethnopharmacology2023

SARS-CoV-2 omicron variants are susceptible in vitro to Artemisia annua hot water extracts.

M S Nair, Y Huang, M Wang, P J Weathers

Open access · hybridAbstract read
In one paragraph

Article in Journal of ethnopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Effect of Water Extract ofAnimals : an open access journal from MDPI · 2026
    Article
  2. Immunomodulatory Effect ofAnimals : an open access journal from MDPI · 2025
    Article
  3. Study on the Regulatory Effect of Water Extract ofAntioxidants (Basel, Switzerland) · 2025
    Article
  4. Review
  5. Profiling of sesquiterpenoid fractions fromBiomolecules & biomedicine · 2025
    Article
  6. Effects of diet supplemented with water extracts ofFrontiers in veterinary science · 2025
    Article
  7. The Antiviral and Antimalarial Prodrug Artemisinin from theCurrent issues in molecular biology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Effects of water extracts ofFrontiers in microbiology · 2024
    Article
  12. The mint versus Covid hypothesis.Medical hypotheses · 2023
    Article
  13. Pathogens (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M S NairAaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: mn2947@cumc.columbia.edu.
Y HuangAaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: yh3253@cumc.columbia.edu.
M WangAaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: hw2614@cumc.columbia.edu.
P J WeathersDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, 01609, USA. Electronic address: weathers@wpi.edu.
Aaron Diamond AIDS Research Center · USWorcester Polytechnic Institute · US

Funding

Study how the liver alters bioavailability of artemisinin when delivered from the dried leaves of the plant Artemisia annua vs as pure drug.R15AT008277 · NCCIH · WORCESTER POLYTECHNIC INSTITUTE · PI WEATHERS, PAMELA J · 2014 to 2018
$953k
NCCIH NIH HHS R15 AT008277
6 · The paper itself

Abstract

ethnopharmacological relevanceArtemisia annua L. has >2000 yr of history in treating fever a symptom common to many infectious diseases including viruses. The plant is widely used as a tea infusion in many areas of the globe to thwart many infectious diseases. AIM OF THE STUDY: The SARS-CoV-2 (COVID-19) virus continues to infect millions while rapidly evolving new variants that are more transmissible and evade vaccine-elicited antibodies, e.g., omicron and its subvariants. Having shown potency against all previously tested variants, A. annua L. extracts were further tested against highly infectious omicron and its recent subvariants. MATERIALS AND

methodsUsing Vero E6 cells, we measured the in vitro efficacy (IC

resultsWhen normalized to the artemisinin (ART) or leaf dry weight (DW) equivalent of the extract, the IC

conclusionsA. annua hot-water extracts (tea infusions) continue to show efficacy against SARS-CoV-2 and its rapidly evolving variants and deserve greater attention as a possible cost-effective therapeutic.

Indexed as

Artemisia annuaCOVID-19Angiotensin-Converting Enzyme 2ArtemisininsHumansSARS-CoV-2TeaAngiotensin-Converting Enzyme 2artemisininArtemisininsTeaArtemisia annuaBA.1BA.2BA.2.12.1BA.4COVID-19OmicronSARS-CoV-2Tea infusionsWA1

Identifiers

PMID36804200
PMCPMC9937997
OpenAlexW4321254275

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.