Evidence map›Paper›PMID 36804398›Full record

ReviewNeuroscience and biobehavioral reviews2023

Quantifying aberrant approach-avoidance conflict in psychopathology: A review of computational approaches.

Allison M Letkiewicz, Haley C Kottler, Stewart A Shankman, Amy L Cochran

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  6. Difficult-to-Treat Anxiety: A Neurocomputational Framework.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Manipulation of interoceptive signaling biases decision making in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Article
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  15. Interoceptive Signals Bias Decision Making in Rhesus Macaques.bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Allison M LetkiewiczDepartment of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA. Electronic address: allison.letkiewicz@northwestern.edu.
Haley C KottlerDepartment of Mathematics, University of Wisconsin, Madison, WI, USA.
Stewart A ShankmanDepartment of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA; Department of Psychology, Northwestern University, Evanston, IL, USA.
Amy L CochranDepartment of Mathematics, University of Wisconsin, Madison, WI, USA; Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)TL1TR001423 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCCOLLEY, SUSANNA A · 2015 to 2023
$5.0M
An examination of psychomotor disturbance in current and remitted MDD: An RDoC StudyR01MH118741 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MITTAL, VIJAY A, SHANKMAN, STEWART AARON · 2019 to 2023
$3.4M
Clarifying the Role of Psychomotor Retardation in Reward-Based Reinforcement Learning Deficits in MDD: A Computational and fMRI StudyK23MH129607 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Allison Letkiewicz · 2023 to 2026
$726k
Modeling mood course to detect markers for effective adaptive interventionsK01MH112876 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI COCHRAN, AMY LOUISE · 2017 to 2020
$511k
NCATS NIH HHS TL1 TR001423NIMH NIH HHS K01 MH112876NIMH NIH HHS K23 MH129607NIMH NIH HHS R01 MH118741
6 · The paper itself

Abstract

Making effective decisions during approach-avoidance conflict is critical in daily life. Aberrant decision-making during approach-avoidance conflict is evident in a range of psychological disorders, including anxiety, depression, trauma-related disorders, substance use disorders, and alcohol use disorders. To help clarify etiological pathways and reveal novel intervention targets, clinical research into decision-making is increasingly adopting a computational psychopathology approach. This approach uses mathematical models that can identify specific decision-making related processes that are altered in mental health disorders. In our review, we highlight foundational approach-avoidance conflict research, followed by more in-depth discussion of computational approaches that have been used to model behavior in these tasks. Specifically, we describe the computational models that have been applied to approach-avoidance conflict (e.g., drift-diffusion, active inference, and reinforcement learning models), and provide resources to guide clinical researchers who may be interested in applying computational modeling. Finally, we identify notable gaps in the current literature and potential future directions for computational approaches aimed at identifying mechanisms of approach-avoidance conflict in psychopathology.

Indexed as

AlcoholismDecision MakingAnxietyAnxiety DisordersAvoidance LearningHumansLearningApproach-avoidance conflictComputational modelingDecision-making

Identifiers

PMID36804398
PMCPMC10023482

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.