ArticleThe Plant cell2023
An ancestral role for 3-KETOACYL-COA SYNTHASE3 as a negative regulator of plant cuticular wax synthesis.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- The chromosome-level genomes of twoHorticulture research · 2026Article
- Seed Priming with Gibberellic Acid Enhances Drought Tolerance in Sweet Sorghum by Modulating Cuticular Wax and Cutin Composition.Plants (Basel, Switzerland) · 2026Article
- Single-Cell Transcriptomics Reveals FLS2-Dependent Hypoxia Signaling and ERF13-Mediated Transcription During flg22-Triggered Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Engineering resilient roses: molecular insights into biotic and abiotic stress adaptation.Horticulture research · 2026Article
- The Role and Regulatory Mechanisms of Cuticular Wax in Crop Stress Tolerance and Yield.Plants (Basel, Switzerland) · 2026Review
- Loss-of-Function Mutation in CER2-LIKE1 Reduced Accumulation of Cuticular Wax and Susceptibility to Thrips in Welsh Onion.Plant biotechnology journal · 2026Article
- Phenotypic characterization of a dominant glossy mutant and fine mapping ofFrontiers in plant science · 2026Article
- Structural basis of VLCFA chain-length determination by the KCS6-CER2 complex in plants.Science advances · 2025Article
- Identification of a Leaf Cuticular Wax Biosynthesis GenePlants (Basel, Switzerland) · 2025Article
- Single-cell transcriptomic analyses reveal cellular and molecular patterns of rose petal responses to gray mold infection.Horticulture research · 2025Article
- Genome-Wide Analysis ofGenes · 2025Article
- Genome-wide analysis of the KCS gene family in Medicago truncatula and their expression profile under various abiotic stress.Scientific reports · 2025Article
- Integrated Transcriptomics and Metabolomics Analysis Reveals Convergent and Divergent Key Molecular Networks of Dominant Genic Male Sterility and Cytoplasmic Male Sterility in Cabbage.International journal of molecular sciences · 2025Article
- How the Ectopic Expression of the BarleyInternational journal of molecular sciences · 2025Article
- Water stress reduces cellulose deposition in the cell wall and increases wax content, resulting in decreased fiber quality.Frontiers in plant science · 2025Article
- A β-ketoacyl-CoA synthase encoded by DDP1 controls rice anther dehiscence and pollen fertility by maintaining lipid homeostasis in the tapetum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Single-nucleus RNA and ATAC sequencing analyses provide molecular insights into early pod development of peanut fruit.Plant communications · 2024Article
- Dynamic relationships among pathways producing hydrocarbons and fatty acids of maize silk cuticular waxes.Plant physiology · 2024Article
- Transcription Factor TaMYB30 Activates Wheat Wax Biosynthesis.International journal of molecular sciences · 2023Article
- Genome-wide identification and expression analysis of theFrontiers in plant science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant cuticle, a structure primarily composed of wax and cutin, forms a continuous coating over most aerial plant surfaces. The cuticle plays important roles in plant tolerance to environmental stress, including stress imposed by drought. Some members of the 3-KETOACYL-COA SYNTHASE (KCS) family are known to act as metabolic enzymes involved in cuticular wax production. Here we report that Arabidopsis (Arabidopsis thaliana) KCS3, which was previously shown to lack canonical catalytic activity, instead functions as a negative regulator of wax metabolism by reducing the enzymatic activity of KCS6, a key KCS involved in wax production. We demonstrate that the role of KCS3 in regulating KCS6 activity involves physical interactions between specific subunits of the fatty acid elongation complex and is essential for maintaining wax homeostasis. We also show that the role of the KCS3-KCS6 module in regulating wax synthesis is highly conserved across diverse plant taxa from Arabidopsis to the moss Physcomitrium patens, pointing to a critical ancient and basal function of this module in finely regulating wax synthesis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.