Evidence map›Paper›PMID 36809045›Full record

ArticlemBio2023

Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses.

David Arranz-Solís, David Warschkau, Benedikt T Fabian, Frank Seeber, Jeroen P J Saeij

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Seroprevalence ofPathogens (Basel, Switzerland) · 2025
    Article
  9. UnderstandingFrontiers in veterinary science · 2025
    Article
  10. Proteomic identification of aFEMS microbes · 2025
    Article
  11. Establishment of an ELISA for detecting oocyst-derivedFrontiers in veterinary science · 2025
    Article
  12. Article
  13. Article
  14. Limited value of current and newFrontiers in parasitology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

David Arranz-Solís *Pathology, Microbiology and Immunology Department, School of Veterinary Medicine, University of California Davis, Davis, California, USA.ORCID 0000-0002-2647-3194
David Warschkau *Mycotic and Parasitic Agents and Mycobacteria (FG16), Robert Koch Institute, Berlin, Germany.ORCID 0000-0002-5288-5408
Benedikt T FabianMycotic and Parasitic Agents and Mycobacteria (FG16), Robert Koch Institute, Berlin, Germany.ORCID 0000-0002-8316-2392
Frank SeeberMycotic and Parasitic Agents and Mycobacteria (FG16), Robert Koch Institute, Berlin, Germany.ORCID 0000-0002-2271-3699
Jeroen P J SaeijPathology, Microbiology and Immunology Department, School of Veterinary Medicine, University of California Davis, Davis, California, USA.ORCID 0000-0003-0289-7109
Robert Koch Institute · DEUniversity of California, Davis · US

Funding

Regulatory factors that determine Toxoplasma bradyzoite to merozoites conversion.R21AI139387 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SAEIJ, JEROEN · 2018 to 2019
$432k
Toxoplasma sporozoite genes that determine environmental resistance and invasion of host cells.R21AI170976 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SAEIJ, JEROEN · 2022 to 2023
$419k
NIAID NIH HHS R21 AI139387NIAID NIH HHS R21 AI170976
6 · The paper itself

Abstract

Toxoplasma gondii oocysts, which are shed in large quantities in the feces from infected felines, are very stable in the environment, resistant to most inactivation procedures, and highly infectious. The oocyst wall provides an important physical barrier for sporozoites contained inside oocysts, protecting them from many chemical and physical stressors, including most inactivation procedures. Furthermore, sporozoites can withstand large temperature changes, even freeze-thawing, as well as desiccation, high salinity, and other environmental insults; however, the genetic basis for this environmental resistance is unknown. Here, we show that a cluster of four genes encoding Late Embryogenesis Abundant (LEA)-related proteins are required to provide

Indexed as

Intrinsically Disordered ProteinsToxoplasmaAnimalsCatsCryoprotective AgentsEscherichia coliLactate DehydrogenasesOocystsSporozoitesCryoprotective AgentsIntrinsically Disordered ProteinsLactate Dehydrogenasesenvironmental resistanceintrinsically disordered proteinslate embryogenesis abundant proteinsoocystssporozoiteToxoplasma gondii

Identifiers

PMID36809045
PMCPMC10128015
OpenAlexW4321452645

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.