Trial reportEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2023
Reproducibility of bolus versus continuous thermodilution for assessment of coronary microvascular function in patients with ANOCA.
Trial report in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05825339 (Absolute Flow for Ischemia With No Obstructive Coronary Arteries), which is not on this map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Absolute Flow for Ischemia With No Obstructive Coronary Arteries
Who cites it
45 citing papers in PubMed.
- Left Ventricular Unloading in Nonischemic Dilated Cardiomyopathy Improves Coronary Haemodynamic Reserve.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Trial
- Improvement of invasive microvascular indices following guideline-directed treatment of structural coronary microvascular dysfunction: a case report.European heart journal. Case reports · 2026Article
- Impact of Coronary Microvascular Dysfunction on Patient-Reported Symptoms After PCI.JACC. Advances · 2026Article
- The Contemporary Role of Intracoronary Physiological Assessment: Fractional Flow Reserve, Non-Hyperemic Pressure Ratios, Wireless Technologies, and Microcirculation.Journal of cardiovascular development and disease · 2026Review
- Acute Changes in Coronary Microvascular Physiology After Supersaturated Oxygen Therapy in Anterior STEMI.JACC. Case reports · 2026Article
- Coronary Flow Reserve in Adults: Pathophysiology, Assessment Modalities, Clinical Applications, and Prognostic Significance.Medicina (Kaunas, Lithuania) · 2026Review
- Beyond Stenosis: Mechanism-Based Multimodality Imaging and Invasive Coronary Function Testing for Endotype Definition in ANOCA/INOCA.Medicina (Kaunas, Lithuania) · 2026Review
- Microvascular Resistance Reserve (MRR): a new concept to understand the coronary microcirculation.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Review
- Absolute coronary blood flow measurement and the principle of microvascular resistance reserve.Cardiovascular intervention and therapeutics · 2026Review
- Differential Effects of Intravenous Versus Intracoronary Adenosine on Non-Culprit Lesion Assessment Following Acute Coronary Syndrome.Journal of the American Heart Association · 2025Article
- Invasive Endotyping of Angina Pectoris with Nonobstructive Coronary Arteries.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025Review
- Impact of Procedural Differences on Bolus Thermodilution Method for Assessment of Coronary Microvascular Dysfunction.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- Comparative Evaluation of Resting and Hyperemic Angiography-Derived Index of Microcirculatory Resistance in Chronic Coronary Syndrome.Journal of the American Heart Association · 2025Article
- Persistent Angina With Nonobstructive Coronary Artery Disease: Unmasking Coronary Microvascular Dysfunction Post-Oncotherapy.JACC. Case reports · 2025Article
- Homogeneity of the coronary microcirculation in angina with non-obstructive coronary artery disease.European heart journal. Cardiovascular Imaging · 2025Article
- Focusing on microvascular function in heart failure with preserved ejection fraction.Heart failure reviews · 2025Review
- Repeatability and Correlation of Coronary Physiology Indices Measured With Bolus and Continuous Thermodilution.Circulation. Cardiovascular interventions · 2025Article
- Coronary Microvascular Dysfunction and Vasospastic Angina-Pathophysiology, Diagnosis and Management Strategies.Journal of clinical medicine · 2025Review
- Known yet underdiagnosed: Invasive assessment of coronary microvascular disease and its implications.World journal of cardiology · 2025Article
- Bringing order to chaos. Invasive functional assessment for all patients in the cath lab?EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA bolus thermodilution-derived index of microcirculatory resistance (IMR) has emerged as the standard for assessing coronary microvascular dysfunction (CMD). Continuous thermodilution has recently been introduced as a tool to quantify absolute coronary flow and microvascular resistance directly. Microvascular resistance reserve (MRR) derived from continuous thermodilution has been proposed as a novel metric of microvascular function, which is independent of epicardial stenoses and myocardial mass.
aimsWe aimed to assess the reproducibility of bolus and continuous thermodilution in assessing coronary microvascular function.
methodsPatients with angina and non-obstructive coronary artery disease (ANOCA) at angiography were prospectively enrolled. Bolus and continuous intracoronary thermodilution measurements were obtained in duplicate in the left anterior descending artery (LAD). Patients were randomly assigned in a 1:1 ratio to undergo either bolus thermodilution first or continuous thermodilution first.
resultsA total of 102 patients were enrolled. The mean fractional flow reserve (FFR) was 0.86±0.06. Coronary flow reserve (CFR) calculated with continuous thermodilution (CFR
conclusionsIn the assessment of coronary microvascular function, continuous thermodilution demonstrated significantly less variability on repeated measurements than bolus thermodilution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.